Figure 5.

Effect of L-type blockers on calcium currents. (A) Calcium currents evoked from holding potential of −70 mV were reduced by nimodipine (10 μmol/L) and abolished by addition of mibefradil (1 μmol/L). (B) Group data n=10 cells. (C, D) After inhibition of L-type currents with nifedipine (C) or nimodipine (D), window currents were left shifted due to a significant change in the activation and inactivation curves of the dihydropyridine-resistant current (see Supplementary Table 3 for details). (E) Calcium currents evoked from holding potential of −70 mV were reduced by nifedipine (1 μmol/L), but not affected by addition of diltiazem (10 μmol/L). (F) Group data n=4 cells.