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. 2010 Feb 3;30(6):1226–1239. doi: 10.1038/jcbfm.2010.11

Figure 6.

Figure 6

Effect of L- and T-type blockers on calcium currents. (A) Calcium currents in SMCs from the main basilar artery, evoked from holding potential of −70 mV, were reduced by nifedipine (1 μmol/L) and abolished by addition of mibefradil (1 μmol/L; n=4 cells). (B) In SMCs from basilar side branches, there was a larger nifedipine-insensitive component (1 μmol/L) that was abolished with mibefradil (1, 3 μmol/L; n=9 cells). (C–F) T-type blockers, mibefradil (1 μmol/L), and NNC 55-0396 (1 μmol/L) blocked all evoked current in SMCs from the main basilar artery. (D, F) Group data n=4 cells.