Table 3. Steno-occlusive disease study.
| Sex | Age (years) | Symptoms | Reason for scan | Right stenosis (%) | Left stenosis (%) | |||
|---|---|---|---|---|---|---|---|---|
| Mild | ||||||||
| PT1 | M | 61 | TIA. Left facial weakness | TIA | 50 | 55 | ||
| PT2 | M | 62 | Left facial weakness | Based on symptoms | 30 | 50 | ||
| PT3 | M | 71 | TIA. Right arm weakness | TIA | 40 | 60 | ||
| PT4 | M | 68 | Slightly blurred bilateral vision/asymptomatic | Before aortic valve replacement | 0 | 30 | ||
| PT5 | M | 83 | Left hand weakness and dysphasia | Based on symptoms | 60 | 55 | ||
| PT6 | M | 75 | Transient global amnesia | Based on symptoms | 40 | 15 | ||
| PT7 | F | 80 | Right leg weakness | Based on symptoms | 60 | 40 | ||
| Mean | 71±8 | |||||||
| Severe | ||||||||
| PT8 | M | 75 | TIA. Right amaurosis fugax | TIA | 80 | 100 | ||
| PT9 | F | 84 | Left arm/leg paraesthesia | Previous common carotid artery ligation | 15 | 100 | ||
| PT10 | M | 76 | Slightly blurred bilateral vision/asymptomatic | Before coronary artery bypass surgery | 80 | 85 | ||
| PT11 | M | 76 | Left Amaurosis Fugax | Based on symptoms | 30 | 80 | ||
| PT12 | M | 62 | Asymptomatic | Recommended based on earlier research scan | 100 | 65 | ||
| PT13 | F | 68 | TIA. Right facial weakness | Based on symptoms | 40 | 80 | ||
| PT14 | F | 61 | Left arm weakness | Right hemispheric ischemic stroke | 100 | 30 | ||
| PT15 | M | 84 | Asymptomatic | Reocclusion of previous right CEA | 100 | 80 | ||
| Mean | 73±9 | |||||||
| Symmetric | ||||||||
| PT16 | M | 74 | Right amaurosis fugax | Based on symptoms | 35 | 35 | ||
| PT17 | M | 75 | Asymptomatic | Left carotid bruit | 100 | 100 | ||
| Mean | 75±1 | |||||||
| aCBV cont (mL/100 mL) | aCBV ips (mL/100 mL) | aCBV cont/ips | CBF cont/ips | MTT cont/ips | DSC CBV cont/ips | MTT-corrected aCBV cont/ips | ||
| Mild | ||||||||
| PT1 | 1.28±1.00 | 1.45±1.46 | 0.88±1.12 | 1.00±0.65 | 0.95±0.39 | 0.94±0.60 | 0.84±1.12 | |
| PT2 | 1.46±1.33 | 1.52±1.27 | 0.96±1.19 | 0.93±0.52 | 1.00±0.36 | 0.95±0.64 | 0.96±1.24 | |
| PT3 | 1.55±1.20 | 1.73±1.52 | 0.90±1.05* | 0.85±0.57* | 0.95±0.44 | 0.83±0.68* | 0.86±1.08* | |
| PT4 | 1.23±1.31 | 1.30±1.45 | 0.95±1.46 | 0.85±0.53* | 1.05±0.38 | 0.84±0.62* | 0.99±1.57 | |
| PT5 | 2.31±1.45 | 2.38±1.57 | 0.97±0.88 | 0.99±0.60 | 0.95±0.33 | 0.96±0.70 | 0.92±0.90 | |
| PT6 | 1.44±1.10 | 1.40±1.04 | 1.03±1.10 | 1.01±0.57 | 1.00±0.28 | 1.01±0.61 | 1.03±1.13 | |
| PT7 | 1.87±1.84 | 1.81±1.53 | 1.03±1.34 | 1.01±0.68 | 1.11±0.50* | 1.12±0.89 | 1.15±1.58* | |
| Mean | 1.59±0.38 | 1.65±0.37 | 0.96±0.06 | 0.95±0.07 | 1.00±0.06 | 0.95±0.10 | 0.96±0.11 | |
| Severe | ||||||||
| PT8 | 1.67±1.73 | 1.45±1.50 | 1.15±1.69* | 1.23±0.78* | 0.83±0.34* | 1.01±0.72 | 0.96±1.46 | |
| PT9 | 1.86±1.64 | 1.52±1.14 | 1.22±1.42* | 1.25±0.76 | 0.90±0.38* | 1.11±0.77* | 1.10±1.35 | |
| PT10 | 1.95±2.65 | 1.66±2.41 | 1.17±2.34* | 1.10±0.66 | 1.13±0.61 | 1.32±1.24 | 1.33±2.74* | |
| PT11 | 1.73±2.03 | 1.96±2.11 | 0.88±1.41 | 1.04±0.62 | 1.01±0.37 | 1.03±0.80 | 0.89±1.46 | |
| PT12 | 1.59±1.67 | 1.62±1.85 | 0.98±1.52 | 0.95±0.72* | 1.09±0.50* | 1.05±0.67* | 1.07±1.73* | |
| PT13 | 1.76±1.86 | 1.67±1.49 | 1.05±1.46 | 0.77±0.54* | 1.18±0.54* | 0.99±0.68 | 1.25±1.82* | |
| PT14 | 1.84±1.50 | 1.45±1.22 | 1.27±1.49* | 1.19±0.82* | 0.92±0.35 | 1.07±0.87* | 1.17±1.44* | |
| PT15 | 1.37±1.13 | 1.28±1.02 | 1.07±1.23* | 0.87±0.47 | 1.06±0.37 | 0.90±0.66 | 1.13±1.36* | |
| Mean | 1.72±0.18 | 1.58±0.20 | 1.10±0.13 | 1.05±0.17 | 1.02±0.12 | 1.06±0.11 | 1.11±0.14 | |
| Symmetric | aCBV right | aCBV left | aCBV right/left | CBF right/left | MTT right/left | DSC CBV right/left | MTT-corrected aCBV right/left | |
| PT16 | 2.46±1.24 | 2.15±1.31 | 1.14±0.90* | 0.87±0.45* | 0.99±0.34 | 1.02±0.77 | 1.13±0.97 | |
| PT17 | 1.52±1.12 | 1.64±1.49 | 0.93±1.08 | 0.94±0.59 | 1.36±0.82* | 1.21±0.87 | 1.26±1.65 | |
| Mean | 1.99±0.66 | 1.90±0.36 | 1.04±0.15 | 0.91±0.05 | 1.18±0.26 | 1.12±0.13 | 1.20±0.10 | |
TIA, transient ischemic attack.
(Above) patient sex, age, symptoms, reason for scan, and right and left stenoses. Maximum stenosis side is identified as ‘ipsilateral,' the opposite side as ‘contralateral.' (Below) patient aCBV values (mean±s.d. over all voxels) and contralateral:ipsilateral ratios for iVASO and DSC. Far right: iVASO-DS MTT-corrected ratios.
(*) Denotes a statistically significant (P<0.01) hemispheric asymmetry.