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. 2010 Mar 10;30(7):1384–1393. doi: 10.1038/jcbfm.2010.22

Figure 4.

Figure 4

13N-ammonia TACs in one representative subject (Ishak score 2, the same subject as in Figure 3). In (A), the time curve of total activity in blood (used for estimation of fbv), the time curve of 13N-ammonia in blood (input function) obtained by population-based metabolite correction from the total blood activity, the TAC in the whole brain VOI, the fit by the irreversible two-tissue compartment model, and the residuals of the fit were shown. Model estimates in this case were delay=3.3 secs (coefficient of variance 12.9%), fbv=3.6% (3.5%), K1=0.158 mL/mL/min (0.6%). In (B), the corresponding Gjedde–Patlak plot that resulted in slope=Kmet=0.115 mL/mL/min (2.2%) and intercept=0.565 mL/mL (19.5%) is shown. The ratio Kmet/K1 was 0.73, and the permeability surface area product PSBBB for ammonia was computed to 0.228 mL/mL/min.