Figure 2.

The time course of the change in [Ca²⁺]_i and tension induced by endothelin-1, thrombin, and phenylephrine in the rabbit basilar artery of the controls and subarachnoid hemorrhage (SAH). Representative recordings (A) and summaries of the time course (B) of [Ca²⁺]_i and tension induced by 100 nmol/L endothelin-1, 1 unit/mL thrombin, and 10 μmol/L phenylephrine in the fura-2-loaded basilar artery of the controls and SAH. In (B), the time course of [Ca²⁺]_i was evaluated at three time points: just before the stimulation (0 min), at the peak of the tension development observed with each agonist (12, 15, or 6 min), and 45 min after the stimulation. The data represent the mean±s.e.m. (n=5 to 7). The levels of [Ca²⁺]_i and tension obtained at rest and 5 mins after initiating a contraction by 118 mmol/L K⁺-physiological salt solution (PSS) were assigned values of 0% and 100%, respectively. ^*P<0.05 versus resting level (0 min); ^#P<0.05; n.s., not significantly different.