Figure 5.

Contractile response of basilar artery to the consecutive stimulation with PAR₁-AP (proteinase-activated receptor 1-activating peptide) and phenylephrine in the controls and subarachnoid hemorrhage (SAH). (A, B) Representative recordings and summary showing the contractile responses to the consecutive stimulation with 100 μmol/L PAR₁-AP (A) and 50 μmol/L phenylephrine (B) in the fura-2-unloaded ring preparations. The rings were consecutively stimulated with PAR₁-AP or phenylephrine for 5 mins with a 10-min interval of incubation without contractile stimulation. The response to the second stimulation was evaluated by assigning the response to the first stimulation to be 100%. The data represent the mean±s.e.m. (n=5). n.s., not significantly different; ^*P<0.05.