Table 1.

CISs Identified in Lymphomas from Eµ-c-Myc Mice with Subphysiological Levels of mdm2

						RTCGDd
							Total
	CIS no.	Chromosome positiona (Chr [Mb])	NCBI accession	Gene description	Eµ-c-Mycb (low mdm2)	Eµ-c-Mycc (wild-type mdm2)	RIS	Tn-IS
CIS with known cancer genes	1.1	10 [20]	NM_033597	myb	11	2	61	0
	1.2	5 [107]	NM_010278	gfi1	6	3	78	0
	1.3	17 [29]	NM_008842	pim1	6	2	34	0
	1.4	2 [18]	NM_007552	pcgf4/bmi1	6	4	17	0
	1.5	2 [117]	NM_011246	rasgrp1	3	4	31	3
	1.6	11 [69]	NM_011640	trp53	3	0	4	0
	1.7	2 [152]	NM_009743	bcl-2l1/bcl-x	3	0	7	0
	1.8	16 [92]	NM_009821	runx1	2	2	9	0
	1.9	19 [37]	NM_008245	hhex	2	0	48	0
CIS with candidate cancer genes	1.10	5 [76]	NM_010612	kdr/flk-1/vegfr2	3	0	10	2
	1.11	11 [74]	NM_001002764	smg6	2	0	9	0
	1.12	9 [71]	NM_011544	tcf12, heb	3	0	4	0
	1.13	2 [158]	NM_153089	ppp1r16b	2	0	4	0
	1.14	6 [72]	NM_138592	usp39	2	0	3	0
	1.15	13 [54]	NM_009946	cplx2	2	0	2	0
	1.16	10 [80]	NM_008655	gadd45β	3	0	1	0
	1.17	13 [118]	NM_010330	emb	2	0	0	0
	1.18	9 [119]	NM_153287	axud1	2	0	0	0

^aChromosomal location of common insertion site (CIS) based on UCSC genome mm8 browser. The chromosome number is followed by the position in megabases [Mb].

^bNumber of M-MuLV retroviral insertions at the indicated locus identified in tumors from Eµ-c-myc mice with a subphysiological level of mdm2 (Eµ-c-myc; mdm2^+/puro, Eµ-c-myc; mdm2^+/Δ7-12 mice, and Eµ-c-myc; mdm2^puro/Δ7-12; n = 74, this study).

^cNumber of M-MuLV retroviral insertion at the indicated locus identified in tumors from Eµ-c-myc mice with wild-type levels of mdm2 (n = 21; Mikkers et al. [2002]¹⁴). Data obtained from Retroviral Tagged Cancer Gene Database (RTCGD).

^dTotal number of retroviral (RIS) and transposon (Tn-IS) insertions at the indicated locus deposited in the RTCGD as of August 2006.