Table 1. Average VH family usage for IgM in HIS (BALB-Rag/γ) mice and control human PBMC.
HIS (BALB-Rag/γ) | Human PBMC | |
VH1 | 0.11±0.03 | 0.40±0.07 |
VH2 | 0.02±0.01 | 0.05±0.04 |
VH3a | 10.2±3.5 | 3.5±0.6 |
VH3b | 75.1±4.4 | 79.9±0.1 |
VH4 | 12.5±3.2 | 11.5±1.7 |
VH5 | 0.03±0.01 | 0.07±0.03 |
VH6 | 0.02±0.01 | 0.030±0.002 |
VH7 | 0.0001±0.0002 | 0.02±0.01 |
The data from HIS mice were generated with B cells isolated from the spleen of naïve animals. The values are expressed as the relative frequency (%) of each IgM-VH family.