TABLE 1.
DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF 95 BILATERAL LUNG TRANSPLANT RECIPIENTS WITH BOS
| Female sex | 40% (40) |
|---|---|
| Mean age at transplant (range), yr | 49 (18–66) |
| Race | |
| White | 91% (86) |
| African American | 9% (9) |
| Native disease | |
| Obstructive | 47% (45) |
| Pulmonary hypertension | 2% (2) |
| Cystic | 21% (20) |
| Restrictive | 30% (28) |
| Transplant era* | 49% (47) |
| Acute rejection history† | |
| Any acute rejection | 73% (69) |
| Acute rejection score‡§ | 3 (2–5) |
| Acute rejection score range§ | 1–15 |
| CMV mismatch (D+/R−) | 23% (22) |
| CMV-pneumonia† | 26% (25) |
| Treatments before BOS | |
| Nissen fundoplication | 41% (39) |
| Antithymocyte globulin | 35% (33) |
| Alemtuzumab | 7% (7) |
| Time to BOS, yr‡ | 3.0 (1.6–4.1) |
| Early-onset BOS‖ | 34% (32) |
| High-grade onset** | 26% (25) |
Definition of abbreviations: BOS = bronchiolitis obliterans syndrome; CMV = cytomegalovirus; D = donor; R = recipient.
Data are presented as % (n) unless otherwise noted.
*
Transplanted after March 2002.
†
Before the onset of BOS.
‡
Median (IQR)
§
Among patients with acute rejection.
‖
BOS onset within 2 years of lung transplant.
**
Initial BOS grade of 2 or 3.