TABLE 2.
IMPACT OF CLINICAL AND DEMOGRAPHIC FACTORS, OCCURRING BEFORE BRONCHIOLITIS OBLITERANS SYNDROME, ON MORTALITY AFTER BRONCHIOLITIS OBLITERANS SYNDROME
| Covariates | HR | 95% CI | P Value |
|---|---|---|---|
| Female sex | 1.28 | 0.72–2.27 | 0.41 |
| Age per yr | 0.99 | 0.97–1.01 | 0.32 |
| Age ≥ 65 yr | 0.75 | 0.18–3.11 | 0.69 |
| White race | 0.98 | 0.41–2.31 | 0.96 |
| Native disease | |||
| Obstructive | 0.72 | 0.40–1.30 | 0.27 |
| Pulmonary hypertension | 2.09 | 0.50–8.76 | 0.31 |
| Cystic | 0.96 | 0.47–2.07 | 0.97 |
| Restrictive | 1.34 | 0.72–2.47 | 0.35 |
| Transplant era* | 1.15 | 0.62–2.11 | 0.71 |
| Acute rejection | |||
| Any acute rejection | 0.86 | 0.47–1.56 | 0.61 |
| Acute rejection score | 0.98 | 0.88–1.09 | 0.77 |
| CMV mismatch (D+/R−) | 1.63 | 0.87–3.06 | 0.13 |
| CMV pneumonitis | 1.30 | 0.66–2.53 | 0.44 |
| Treatments | |||
| Nissen fundoplication | 0.98 | 0.55–1.77 | 0.96 |
| Antithymocyte globulin | 1.09 | 0.56–1.85 | 0.96 |
| Alemtuzumab | 2.28 | 0.89–5.82 | 0.09 |
| Early-onset BOS† | 1.84 | 1.03–3.29 | 0.04 |
| High-grade onset‡ | 2.40 | 1.34–4.32 | 0.003 |
Definition of abbreviations: BOS = bronchiolitis obliterans syndrome; CI = confidence interval; CMV = cytomegalovirus; D = donor; HR = hazard ratio; R = recipient.
*
Transplanted after March 2002.
†
BOS onset within 2 years of lung transplant.
‡
Initial BOS grade of 2 or 3.