TABLE 2.

ESTIMATED RELATIVE MEAN CHANGE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 WHEN APNEA-HYPOPNEA INDEX IS MODELED USING A PIECEWISE LINEAR ASSOCIATION (N = 536)

	Estimated Relative Mean Change in PAI-1 Given a 5-Unit Increase in AHI (95% CI)	Test if No Relative Mean Change in PAI-1 Given a 5-Unit Increase in AHI	Test if Relative Mean Change in PAI-1 is the Same for Both AHI Groups
PAI-1 a.m. (ng/ml)*
Model 1
AHI < 15	1.26 (1.17–1.36)†	< 0.001	< 0.001
AHI ≥ 15	1.01 (0.98–1.04)	0.44
Model 2
AHI < 15	1.12 (1.05–1.19)	0.001	0.002
AHI ≥ 15	0.99 (0.97–1.01)	0.35
Model 3
AHI < 15	1.10 (1.03–1.17)	0.003	0.01
AHI ≥ 15	0.99 (0.97–1.01)	0.34
PAI-1 p.m. (ng/ml)*
Model 1
AHI < 15	1.25 (1.14–1.36)	< 0.001	< 0.001
AHI ≥ 15	1.01 (0.98–1.04)	0.47
Model 2
AHI < 15	1.11 (1.02–1.20)	0.01	0.02
AHI ≥ 15	0.99 (0.96–1.01)	0.34

Definition of abbreviations: AHI = apnea-hypopnea index; CI = confidence interval; PAI-1 = plasminogen activator inhibitor-1.

Model 1: AHI + age, race, sex. Model 2: Model 1 + BMI, cardiac disease/cerebrovascular disease, hypertension, diabetes mellitus, aspirin use, oral contraceptive use, current smoker status, and menopausal status. Model 3: Model 2 + PAI-1 p.m.

^*PAI-1 a.m. and PAI-1 p.m. are log transformed to satisfy the assumption of normality in the model. Parameter estimates are then back transformed for ease of model interpretation.

^†For AHI < 15, when AHI increases by 5 units, the mean of PAI-1 a.m. increases by 26% (1.26; 95% CI, 1.17–1.36) adjusting for age, race, and sex.