Table 2.

Summary of Gefitinib Effects on Response of EGF Signalling and Cell Cycle Pathway Genes to Luteolin

Gene	35 µM Luteolin	44 µM Gefitinib	35 µM Luteolin + 44 µM Gefitinib	Gefitinib Effect on Luteolin Response
EGFR	12.7 ± 0.5	128.3 ± 3.2	56.3 ± 1.8	M to N
c-Fos	409.0 ± 9.1	27.7 ± 0.7	422.0 ± 7.4	N
SOS	18.3 ± 2.3	112.7 ± 11.3	10.3 ± 1.0	N
GRB2	31.3 ± 1.2	87.3 ± 1.4	42.0 ± 1.1	N
JNK-1	32.7 ± 1.0	88.3 ± 3.5	52.3 ± 1.6	M to N
MKK4	28.0 ± 0.9	89.0 ± 2.8	11.0 ± 0.5	N
RasGAP	21.7 ± 0.8	75.7 ± 1.8	21.3 ± 0.8	N
CDKN1B	106.3 ± 1.9	102.0 ± 3.5	141.0 ± 4.0	N
CCNA2	10.3 ± 1.9	40.0 ± 0.7	1.7 ± 0.2	E
PCNA	21.0 ± 0.6	41.0 ± 1.3	2.7 ± 0.1	E
CCNE2	66.3 ± 2.0	36.3 ± 0.9	5.7 ± 0.2	E
PLK1	7.7 ± 0.2	30.0 ± 0.5	8.7 ± 0.3	N
CDC25A	27.3 ± 1.0	25.0 ± 0.9	1.3 ± 0.1	E

N=None, M to N= minimal to None, E=Enhance

Values represent the numerical data used to generate Figure 8.