Table 3.

Association of Pre-Treatment Brain Regional Mu-Opioid Receptor Binding and Cubic-Root Transformed Longest Duration of Abstinence (Weeks) from Cocaine Achieved during Treatment (n=25)

Brain	SPM Result (voxel-level)			Correlation Using Mean Value from the Cluster
Region	MNI^a (x,y,z)	Max-z	T-value (df=23)	k^b	r²	p-value
(A) Middle Temporal Gyrus Left extending to Sub-lobar Insula Left	−48, 2, −30	4.23	5.28	1832	0.46	<0.001
(B) Middle Temporal Gyrus Right	36, 2, −42	3.92	4.75	830	0.45	<0.001
(C) Medial Frontal Gyrus Left	−10, 6, 54	3.78	4.51	900	0.42	<0.001
(D) Middle Temporal Gyrus Right	54, −44, −12	3.68	4.36	329	0.44	<0.001
(E) Middle Frontal Gyrus Left	−40, 32, 34	3.52	4.1	91	0.40	<0.001
(F) Anterior Cingulate Gyrus Left	−4, −14, 40	3.38	3.9	50	0.39	<0.001
(G) Middle Frontal Gyrus Right	44, 40, 14	3.33	3.83	68	0.39	<0.001

SPM, statistical parametric mapping; MNI, Montreal Neurological Institute

Location of peak expressed as x,y,z coordinates in MNI space.

Cluster size k represents number of voxels (2 × 2 × 2 mm³) at a height threshold of p = .001, uncorrected. A correlation was considered significant if a cluster of ≥50 contiguous voxels exceeded an uncorrected peak threshold of P<0.001 (23).