Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2010 Aug 19;94(3):353–363. doi: 10.1016/j.nlm.2010.08.001

Figure 5. Effects of nicotinic antagonist infusion into the medial prefrontal cortex on trace fear conditioning.

Figure 5

A. Infusion of DHβE into the medial prefrontal cortex at training and testing dose-dependently (9.00 and 18.00 μg/side) enhanced trace fear conditioning but not contextual conditioning (n = 8 – 9). B. Infusion of 9.00 μg/side DHβE into the medial prefrontal cortex at training enhanced trace conditioning, but infusion at testing produced deficits in both trace and contextual conditioning (n = 8). C. Infusion of MLA (13.50 and 27.00 μg/side) into the medial prefrontal cortex at training and testing enhanced trace fear conditioning but did not affect contextual conditioning (n = 9 – 10). D. Infusion of 13.50 μg/side MLA into the medial prefrontal cortex at training enhanced trace conditioning, but infusion at testing produced deficits in both trace and contextual conditioning (n = 8). Significant difference (p < 0.05) from the saline-infused control group denoted with (*); data are reported as mean ± standard error of the mean. Representations of cannula placements alongside data demonstrate that all infusions were directed into the medial prefrontal cortex.