Table 1.

Characteristics of women with a RRSO performed 2001–2008 after disclosure of a positive BRCA1/2 test

Variable	Total sample			BRCA1			BRCA2
	OOC (N = 16)	No ovarian cancer (N = 631)	P-value	OOC (N = 12)	No ovarian cancer (N = 376)	P-value	OOC (N = 4)	No ovarian cancer (N = 255)	P-value
Mean birth year (range)	1951 (1928–1967)	1957 (1927–1978)	0.007	1955 (1944–1967)	1958 (1927–1978)	0.175	1941 (1928–1949)	1955 (1929–1971)	0.001
Mean age at RRSO, years (range)	51.7 (35.6–76.4)	46.6 (25.8–75.3)	0.017	48.1 (35.6–60.4)	45.4 (25.8-75.3)	0.249	62.4 (56.1–76.4)	48.4 (33.1–72.9)	0.001
Mean RRSO year (range)	2003 (2001–2005)	2003 (2001–2008)	0.231	2003 (2001–2005)	2003 (2001–2007)	0.433	2003 (2001–2005)	2004 (2001–2008)	0.393
Parous (%)	11 (69%)	413 (78%)	0.378	7 (58%)	244 (78%)	0.156	4 (100%)	169 (77%)	0.577
Mean number of live births (range)	2.1 (2–3)	2.5 (2–8)	0.094	2.1 (2–3)	2.5 (2–5)	0.226	2 (2–2)	2.5 (2–8)	0.244
Ever user of oral contraceptives (%)	9 (60%)	466 (82%)	0.046	8 (73%)	283 (84%)	0.395	1 (25%)	183 (78%)	0.039
Ever smoker (%)	9 (60%)	246 (42%)	0.190	9 (75%)	146 (42%)	0.036	0	100 (41%)	0.273*
Breast cancer diagnosis prior to RRSO (%)	8 (50%)	355 (56%)	0.621	5 (42%)	209 (56%)	0.387	3 (75%)	146 (57%)	0.639
Mean age at breast cancer diagnosis (range)	42.6 (28.0–55.2)	42.2 (24.3–70.6)	0.886	37.9 (28.0–55.2)	40.2 (24.3–60.0)	0.475	50.4 (48.5–52.0)	44.9 (25.7–70.6)	0.233
Mean time from genetic testing to RRSO	0.86 (0.003–6.12)	1.01 (0–9.14)	0.679	0.94 (0.003–6.12)	1.03 (0–9.13)	0.835	1.10 (0.06–3.07)	1.39 (0.01–8.48)	0.833

^*Exact confidence levels not possible with zero count cells