Table 3.
Qualitative analysis of hypothermia-suppressed genes using PubMatrix.
| Pubmed Search Terms | |||||||
|---|---|---|---|---|---|---|---|
| Gene Title | Gene Symbol | Neutrophil | Endothelium | Epithelium | Pulmonary | Ratio PMN/Tissue | Distribution |
| Neutrophil cytosolic factor 1 | Ncf1 | 44 | 0 | 0 | 2 | 44.00 | PMN |
| Neutrophil cytosolic factor 2 | Ncf2 | 17 | 0 | 0 | 3 | 17.00 | |
| Lipocalin-2 | Lcn2 | 256 | 5 | 26 | 39 | 8.26 | |
| chemokine ligand 2 | Cxcl2 | 664 | 44 | 88 | 463 | 5.03 | |
| chemokine ligand 1 | Cxcl1 | 761 | 94 | 162 | 269 | 2.97 | |
| biregional cell adhesion molecule-related/down-regulated by oncogenes binding protein | Boc | 72 | 7 | 23 | 57 | 2.40 | |
| chemokine ligand 3 | Ccl3 | 248 | 55 | 76 | 249 | 1.89 | |
|
| |||||||
| Lipopolysaccharide binding protein | Lbp | 95 | 28 | 51 | 96 | 1.20 | Even |
| CD 14 Antigen | Cd14 | 658 | 300 | 381 | 533 | 0.97 | |
| Tumor necrosis factor receptor superfamily 12 | Tnfrsf1a | 19 | 8 | 13 | 17 | 0.90 | |
|
| |||||||
| MAP kinase-acitvated protein kinase 2 | Mapkapk2 | 25 | 23 | 27 | 20 | 0.50 | Tissue |
| CSX-associated LIM | Cal | 33 | 18 | 51 | 168 | 0.48 | |
| signal transducer and activator of transcription 3 | Stat3 | 158 | 111 | 253 | 342 | 0.43 | |
| Coagulation factor 3 | F3 | 22 | 15 | 42 | 69 | 0.39 | |
| spermidine/spermine N1-acetyl transferase | Sat | 18 | 19 | 40 | 182 | 0.31 | |
| inhibitor of kappaB kinase beta | Ikbkb | 61 | 80 | 138 | 166 | 0.28 | |
| complement component 4 gene 2 | C4-2 | 4 | 3 | 12 | 7 | 0.27 | |
| plasminogen activator tissue | Plat | 10 | 19 | 19 | 24 | 0.26 | |
| desmin | Des | 630 | 755 | 1663 | 3266 | 0.26 | |
| guanine deaminase | Gda | 8 | 9 | 22 | 95 | 0.26 | |
| prostaglandin-endoperoxide synthase 2 | Ptgs2 | 397 | 605 | 1046 | 1139 | 0.24 | |
| period homolog 1 | Per1 | 2 | 1 | 8 | 18 | 0.22 | |
| NAD(P)H dehydrogenase quinone 1 | Nqo1 | 10 | 18 | 29 | 140 | 0.21 | |
| ectonucleotide pyrophosphatase/phosphodiesterase2 | Enpp2 | 2 | 2 | 8 | 10 | 0.20 | |
| runt related transcription factor 1 | Runx1 | 12 | 34 | 38 | 10 | 0.17 | |
| gap junction membrane channel protein alpha 1 | Gja1 | 2 | 5 | 10 | 8 | 0.13 | |
| Kirsten rat sarcoma viral oncogene homologue 2 (active) | Kras2 | 25 | 44 | 152 | 265 | 0.13 | |
| vasodilator-stimulated phosphoprotein | Vasp | 13 | 50 | 54 | 21 | 0.13 | |
| secreted phosphoprotein 1 | Spp1 | 22 | 43 | 137 | 79 | 0.12 | |
| Tissue inhibitor of metalloproteinase 1 | Timp1 | 5 | 13 | 28 | 35 | 0.12 | |
| matrix Gla protein | Mgp | 5 | 17 | 34 | 36 | 0.10 | |
| oxidized low density lipoprotein (lectin-like) receptor 1 | Oldlr1 | 3 | 16 | 15 | 1 | 0.10 | |
| elongation factor RNA polymerase II | Ell | 2 | 3 | 20 | 74 | 0.09 | |
| neurturin | Nrtn | 1 | 1 | 12 | 1 | 0.08 | |
| P450 (cytochrome) oxidoreductase | Por | 5 | 18 | 49 | 124 | 0.07 | |
| glutathione peroxidase 2 | Gpx2 | 1 | 0 | 14 | 9 | 0.07 | |
| activating transcription factor 4 | Atf4 | 1 | 7 | 14 | 12 | 0.05 | |
| Kruppel-like factor 5 | Klf5 | 1 | 7 | 20 | 4 | 0.04 | |
| insulin-like growth factor 1 receptor | Igf1r | 7 | 59 | 158 | 161 | 0.03 | |
| hyaluronan synthase 1 | Has1 | 1 | 12 | 22 | 17 | 0.03 | |
| forkhead box A2 | Foxa2 | 1 | 3 | 45 | 61 | 0.02 | |
| wingless-related MMTV integration site 4 | Wnt4 | 0 | 1 | 26 | 5 | 0.04 | |
| solute carrier family 7 (cationic amino acid transporter y+ system) member 1 | Slc7a1 | 0 | 12 | 11 | 5 | 0.04 | |
| tumor-associated protein 1 (Slc7a5) | Slc7a5 | 0 | 6 | 13 | 13 | 0.05 | |
| procollagen type VII alpha 1 | Col7a1 | 0 | 0 | 13 | 0 | 0.08 | |
| laminin alpha 5 | Lama5 | 0 | 2 | 10 | 4 | 0.08 | |
| low density lipoprotein receptor-related protein 6 | Lrp6 | 0 | 0 | 10 | 4 | 0.10 | |
| huntingtin-associated protein 1 (Hap1) transcript variant 2 | Hap1 | 0 | 2 | 7 | 13 | 0.11 | |
| surfactant associated protein B | Sftpb | 0 | 0 | 7 | 48 | 0.14 | |
Genes that had at least 10 hits in one category were retained. For calculation of PMN/Tissue ratio zeroes were substituted with 1.