Table 5.
Recovery of C. trachomatis MoPn from the newborn mice
| Newborn mice born and fed by: | PND | No. culture + newborn mice (%+) and median (range) no. of IFU recovered from organs: |
|||||
|---|---|---|---|---|---|---|---|
| Lungs (×106) | Intestine (×106) | Spleen | |||||
| Immunized-dams | 7 | 9 (75) | 743 (<20–0.8) | 12 (100) | 0.2 (0.002–1,049)a | 4 (33) | <20 (<20–11,000) |
| Sham-immunized-dams | 7 | 9 (82) | 350 (<20–5.3) | 11 (100) | 32 (2.9–270) | 8 (73) | 80 (<20–17,600) |
| Immunized-dams | 18 | 6 (38) | <20 (<20–0.007) | 16 (100) | 9.2 (0.9–128)b | 4 (25) | <20 (<20–3,387) |
| Sham-immunized-dams | 18 | 6 (50) | 30 (<20–2.3) | 12 (100) | 85 (1.2–2,975) | 2 (17) | <20 (<20–21,400) |
a
P<0.05 by the multivariate regression analysis compared with the newborn mice born from and fed by sham-immunized-dams.
b
P<0.1 by the multivariate regression analysis compared with the newborn mice born from and fed by sham-immunized-dams Limit of detection: <20 IFU/culture.