. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Thromb Haemost. 2010 Aug 5;104(4):750–754. doi: 10.1160/TH09-11-0763

Table 3.

Adjustment Factors for Existing Pharmacogenetic Dosing Algorithms, Depending on GGCX Genotype.

GGCX rs11676382 genotype	Formula for Correction Factor^*	Adjustment in African-Americans and Asians^*	Adjustment in Caucasians^*
CC	1 / (P_C² + 2P_CP_G × 0.939 + P_G² × 0.939²)	1.00	1.01
GC	0.939 / (P_C² + 2P_CP_G × 0.939 + P_G² × 0.939²)	0.94	0.95
GG	0.939² / (P_C² + 2P_CP_G × 0.939 + P_G² × 0.939²)	0.88	0.89

multiply predicted dose by this correction factor.

^†P_C = allele frequency of the wildtype C allele.

^‡P_G= allele frequency of the G allele.