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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Ophthalmology. 2010 Sep 1;117(10):1930–1936. doi: 10.1016/j.ophtha.2010.07.010

Table 3.

Corneal subbasal nerve alterations in the control group and in herpes simplex keratitispatients according to grade of hypoesthesia.

Controls and HSK eyes by Sensitivity Subcategory Eyes n (%) Age Mean central corneal sensitivity (cm) Mean subbasal nerve density (μm/μm2) Total nerves (n) Main nerve trunks (n) Total branches (n)

Controls 15 59±17 6.0 ± 0 2258.4 ±989.0 13.1 ± 3.8 4.7 ± 1.2 9.8 ± 3.3

HSK Normal sensation (>5.5cm) 6 (19%) 43.2 ± 23.1 6.0 ± 0 930.9 ± 312.2* (p<0.003) 7.5 ± 3.0* (p<0.002) 3.9 ± 1.8 (p=0.2) 3.6 ± 1.4* (p<0.004)

HSK Mild hypoesthesia (>2.5cm to ≤5.5cm) 12 (39%) 66.5 ± 14 4.1 ± 0.9* (p<0.0001) 518.8 ± 394.6* (p<0.0001) 5.2 ± 2.8* (p<0.0001) 2.3 ± 1.2* (p<0.0001) 4.7 ± 6.1* (p<0.0003)

HSK Severe hypoesthesia (≤2.5cm) 13 (42%) 66.7 ± 17 1.4 ± 1.0* (p<0.0001) 161.8 ± 158.8* (p<0.0001) 3.1 ± 2.7* (p<0.0001) 1.5 ± 1.3* (p<0.0001) 1.5 ± 2.3* (p<0.0001)

p-value within HSK sensation groups:
normal - mild p<0.004 p<0.0002 p<0.01 p<0.04 p<0.003 p=0.32
normal - severe p<0.02 p<0.0001 p<0.001 p<0.002 p<0.001 p<0.002
severe-mild p=0.48 p<0.0001 p<0.004 p<0.04 p=0.059 p<0.008

Herpes simplex keratitis (HSK) patients were grouped into normal (>5.5 cm), mild (>2.5 cm to ≤5.5 cm), and severe (≤2.5 cm) loss of corneal sensation according to the corneal sensitivity threshold measurements with the Cochet-Bonnet esthesiometer. Values reported as mean ± standard deviation. Statistical analysis performed by ANOVA (analysis of variance between groups).

*

Statistically significant compared to controls, P-values shown in parenthesis. P-values compared within sensation groups at the bottom of the table.

HHS Vulnerability Disclosure