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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Cell Res. 2010 Aug 3;20(10):1109–1116. doi: 10.1038/cr.2010.114

Figure 1. lncRNAs are differentially expressed in ES cells, NPCs, and fibroblasts.

Figure 1

(A) Pie chart representation of the distribution of lncRNAs in the mouse genome. Independent Fantom3 lncRNA entries were scanned for overlap with promoters, defined as −1kb to +1kb surrounding the TSS, and coding regions of annotated genes from the REFSEQ database.

(B) Heat map presentation of the expression profile of lncRNAs in ES cells, NPCs, and fibroblasts. The data presented for each cell type was compared to universal reference RNA and was subjected to uncentered hierarchical clustering. ES: embryonic stem cells, NPC: neuroprogenitors, FIB: fibroblasts.

(C) RT-qPCR validation of microarray data for randomly chosen lncRNAs that exhibited at least 2-fold elevated transcription in ES versus both NPCs and fibroblasts.

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