Figure 2. lncRNA promoter H3K4me3 and H3K27me3 patterns in ES cells, NPCs, and fibroblasts.
Distribution of H3K4me3 and H3K27me3 at lncRNA promoters in ES cells, NPCs, and fibroblast cells for (A) all lncRNAs examined and (B) lncRNAs grouped by their epigenetic modification state in ES cells and then assessed for modification in both NPC and fibroblast cells. The presence or absence of H3K4me3 and H3K27me3 peaks was assessed within the promoters of lncRNAs that did not overlap with annotated REFSEQ genes (n=10937) in mouse ES cells, NPCs, and fibroblasts. H3K4me3 only, blue; H3K27me3 only, red; H3K4me3 and H3K27me3 (bivalent), green; no H3K4me3 and no H3K27me3, purple.