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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Cell Res. 2010 Aug 3;20(10):1109–1116. doi: 10.1038/cr.2010.114

Figure 3. Changes in promoter H3K4me3 and H3K27me3 levels are correlated with lncRNA expression.

Figure 3

The average H3K4me3 (A) and H3K27me3 (B) tag density across the promoters of lncRNAs in ES cells grouped by relative expression in ES versus NPC and fibroblast. X-axis represents the region spanning −5kb to +5kb away from the lncRNA transcription start site (TSS). Red line indicates lncRNAs that exhibit at least 2-fold higher expression in ES cells relative to both NPCs and fibroblast cells, E↑N↓F↓ (n=1511). Blue line indicates lncRNAs that exhibit at least 2-fold lower expression in ES cells relative to both NPCs and fibroblast cells, E↓N↑F↑ (n=1696). (C) Box plot presentation of expression change (ES/FIB) in bivalent-marked lncRNAs in ES cells (n=321), which are further divided into three groups according to their promoter H3K4 and H3K27 methylation state in fibroblast cells: H3K4me3 and H3K27me3, Biv (n=115); H3K4me3 only, K4 (n=98); H3K27me3 only, K27 (n=89). Significant p values as determined by Wilcoxon signed-rank test are indicated.

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