Table 2.
Histopathological assessment of the resection specimens in relation to four BMI classes in 556 patients who underwent surgical resection for esophageal cancer
| Underweight BMI < 18.50 N = 40 | Normal weight BMI 18.50–24.99 N = 244 | Overweight BMI 25.00–29.99 N = 214 | Obesity BMI ≥ 30.00 N = 58 | p-value | |
|---|---|---|---|---|---|
| Histology | |||||
| SCC | 22 (55.0%) | 29 (11.9%) | 26 (12.1%) | 6 (10.3%) | |
| AC | 18 (45.0%) | 215 (88.1%) | 188 (87.9%) | 52 (89.7%) | <0.001 |
| pT-status | |||||
| T1–T2 | 10 (25.0%) | 65 (26.6%) | 83 (38.8%) | 23 (39.7%) | |
| T3–T4 | 30 (75.0%) | 179 (73.4%) | 131 (61.2%) | 35 (60.3%) | 0.02 |
| pN-status | |||||
| N0 | 16 (40.0%) | 84 (34.4%) | 81 (37.9%) | 24 (41.4%) | |
| N1 | 24 (60.0%) | 160 (65.6%) | 133 (62.2%) | 34 (58.6%) | 0.94 |
| pM-status | |||||
| M0 | 32 (80.0%) | 194 (79.5%) | 164 (76.6%) | 47 (81.0%) | |
| M1a–M1b | 8 (20.0%) | 50 (20.5%) | 50 (23.4%) | 11 (19.0%) | 0.84 |
| Differentiation grade | |||||
| G1 (good) | 4 (10.0%) | 14 (5.7%) | 17 (7.9%) | 4 (6.9%) | |
| G2 (moderate) | 26 (65.0%) | 111 (45.5%) | 95 (44.4%) | 22 (37.9%) | |
| G3 (poor) | 10 (25.0%) | 119 (48.8%) | 102 (47.7%) | 32 (55.2%) | 0.17 |
| Type of resection | |||||
| R0 | 24 (60.0%) | 167 (68.4%) | 154 (72.0%) | 47 (81.0%) | |
| R1–R2 | 16 (40.0%) | 77 (31.6%) | 60 (28.0%) | 11 (19.0%) | 0.06 |
| Number of positive lymph nodes* | 1 (1–19) | 2 (0–23) | 2 (0–43) | 1 (0–11) | 0.14 |
| Total number of harvested lymph nodes* | 10 (3–45) | 12 (1–56) | 10 (1–43) | 9 (2–31) | 0.10 |
| Lymph node ratio* | 0.10 | 0.17 | 0.16 | 0.10 | 0.14 |
BMI body mass index, SCC squamous cell carcinoma, AC adenocarcinoma, lymph node ratio number of positive lymph nodes/total number of harvested lymph nodes
* Values presented as median (range in brackets)