Table 3.
Correlation between HOXB13 protein levels and prognostic factors analyzed with the chi-square test for trend
| HOXB13 expression | P value | ||||
|---|---|---|---|---|---|
| Negative | Low | Intermediate | High | ||
| Tumor size | |||||
| ≤20 mm | 205 (31.0) | 249 (37.7) | 168 (25.4) | 39 (5.9) | |
| >20 mm | 78 (43.1) | 59 (32.6) | 37 (20.4) | 7 (3.9 | 0.0048 |
| Human epidermal growth factor receptor 2 | |||||
| 0 | 189 (38.4) | 172 (35.0) | 102 (20.7) | 29 (5.9) | |
| 1+ | 38 (26.6) | 55 (38.5) | 45 (31.5) | 5 (3.5) | |
| 2+ | 16 (20.5) | 32 (41.0) | 26 (33.3) | 4 (5.1) | |
| 3+ | 27 (29.7) | 30 (33.0) | 27 (29.7) | 7 (7.7) | 0.0023 |
| Estrogen receptor* | |||||
| 0 | 63 (39.4) | 48 (30.0) | 34 (21.3) | 15 (9.4) | |
| 1 to 24 | 5 (35.7) | 5 (35.7) | 4 (28.6) | 0 (0) | |
| 25 to 74 | 69 (57.0) | 35 (28.9) | 16 (13.2) | 1 (0.8) | |
| 75 to 89 | 63 (33.3) | 67 (35.5) | 47 (24.9) | 12 (6.4) | |
| >90 | 62 (22.1) | 110 (39.3) | 96 (34.3) | 12 (4.3) | 0.0022 |
| Progesterone receptor* | |||||
| 0 | 120 (39.9) | 92 (30.6) | 68 (22.6) | 21 (7.0) | |
| 1 to 24 | 43 (42.6) | 29 (28.7) | 26 (25.7) | 3 (3.0) | |
| 25 to 74 | 58 (29.3) | 87 (43.9) | 48 (24.2) | 5 (2.5) | |
| 75 to 89 | 27 (24.1) | 42 (37.5) | 33 (29.5) | 10 (8.9) | |
| >90 | 20 (36.4) | 21 (38.2) | 12 (21.8) | 2 (3.6) | 0.13 |
Data presented as number of patients (%).*Percentage of positive nuclei stained with immunohistochemistry.