Table 4.
Association of Msx2 with cell cycle-associated and Msx2-interacting genes at the mRNA level within the Van de Vijver dataseta
| Variable | Van de Vivjer data set (n = 295) | |||
|---|---|---|---|---|
| Low Msx2 (n = 74) |
High Msx2 (n = 221) |
P value | Association with Prognosis? |
|
| Survivin | <0.001 | Poor** | ||
| Low | 24 (32.4) | 125 (56.6) | ||
| High | 50 (67.6) | 96 (43.4) | ||
| Cyclin D1 | <0.001 | NS | ||
| Low High |
32 (43.2) 42 (56.8) |
42 (19) 179 (81) |
||
| Cyclin A1 | 0.037 | Poor** | ||
| Low | 49 (66.2) | 173 (78.3) | ||
| High | 25 (33.8) | 48 (21.7) | ||
| Cyclin A2 | 0.007 | Poor** | ||
| Low | 27 (36.5) | 121 (54.8) | ||
| High | 47 (63.5) | 100 (45.2) | ||
| Cyclin B2 | 0.014 | Poor** | ||
| Low | 28 (37.8) | 120 (54.3) | ||
| High | 46 (62.2) | 101 (45.7) | ||
| Cyclin E1 | 0.003 | Poor** | ||
| Low | 46 (62.2) | 175 (79.5) | ||
| High | 28 (37.8) | 45 (20.5) | ||
| DLX5 | 0.077 | Poor* | ||
| Low | 50 (67.6) | 172 (77.8) | ||
| High | 24 (32.4) | 49 (22.2) | ||
| BMP4 | 0.017 | Good** | ||
| Low | 46 (62.2) | 102 (46.2) | ||
| High | 28 (37.8) | 119 (53.8) | ||
aBMP, bone morphogenetic protein; DLX5, distal-less homeobox 5; *P < 0.05 **P < 0.01 (log rank test); otherwise χ2 test.