Table 2.
Morphometry of subpopulations of DRG neurons with strong immunoreactivity (IR) for ATP7A and CTR1 in tissues from control and oxaliplatin-treated animals
| Animal Group | Copper transporter | Frequency of IR neurons (%) |
Small-sized cells ( < 750 μm2) (%) |
Medium-sized cells (750-1750 μm2) (%) |
Large-sized cells ( > 1750 μm2) (%) |
Mean cell body area (μm2) |
|---|---|---|---|---|---|---|
| Control | ATP7A | 35.1 ± 2.9 | 64.2 ± 6.9 | 29.1 ± 4.7 | 6.7 ± 2.5 | 767 ± 88 |
| CTR1 | 10.9 ± 1.8† | 2.0 ± 1.3† | 39.9 ± 15.9 | 58.2 ± 16.1† | 1936 ± 278† | |
| Oxaliplatin treatment | ATP7A | 33.6 ± 2.3 | 70.5 ± 4.0 | 27.1 ± 3.7 | 2.4 ± 1.3 | 641 ± 39 |
| CTR1' | 11.3 ± 3.5 | 5.2 ± 2.0 | 66.4 ± 5.5* | 28.5 ± 5.5* | 1461 ± 64* | |
Values represent the mean ± standard deviation of determinations in 4 to 6 animals per group. † P < 0.01 for comparison with ATP7a control group; * P < 0.01 for comparison with CTR1 control group.