Table 2.
Selected genes upregulated in sorted lung MSCs relative to lung fibroblasts.
| Symbol average | Lung MSCs average | Lung fibroblast | Fold difference | Differential p-value |
|---|---|---|---|---|
| Secreted cytokines and paracrine factors | ||||
| Prl2c3 | 20800 | 2.91 | 7147.77 | 1.00E-13 |
| Prl2c4 | 16700 | 2.49 | 6706.83 | 1.01E-13 |
| Prl2c2 | 16400 | 2.37 | 6919.83 | 1.01E-13 |
| Efnb2 | 250 | 42.4 | 5.90 | 2.98E-08 |
| Prl2c5 | 224 | 71.5 | 3.13 | 7.15E-08 |
| Grem1 | 17700 | 2520 | 7.02 | 1.42E-06 |
| Ptges3 | 2080 | 763 | 2.73 | 1.20E-05 |
| Fgf10 | 3710 | 853 | 4.35 | 0.000233 |
| Ctf1 | 265 | 109 | 2.43 | 0.000226 |
| Ccl25 | 171 | 58.9 | 2.90 | 0.000239 |
| Fgf7 | 7600 | 3580 | 2.12 | 0.00038 |
| Efna4 | 176 | 85.3 | 2.06 | 0.00268 |
| Bmper | 2060 | 1020 | 2.02 | 0.0041 |
| Lefty1 | 411 | 244 | 1.68 | 0.0163 |
| Gdf11 | 52.3 | 7.81 | 6.70 | 0.0279 |
| Thbs1 | 961 | 300 | 3.20 | 0.0293 |
| Cx3cl1 | 384 | 81.6 | 4.71 | 0.0311 |
| Sema3a | 638 | 14.8 | 43.11 | 0.0367 |
| Spp1 | 12500 | 8920 | 1.40 | 0.0469 |
| TGF-β1 signaling | ||||
| Smad2 | 334 | 86.4 | 3.87 | 5.67E-07 |
| Smad3 | 889 | 410 | 2.17 | 5.67E-07 |
| Mapk13 | 387 | 104 | 3.72 | 1.28E-06 |
| Hdac2 | 2440 | 1300 | 1.88 | 1.58E-05 |
| Trrap | 207 | 54.2 | 3.82 | 4.02E-05 |
| Hdac4 | 179 | 69.6 | 2.57 | 0.000433 |
| Mapk11 | 115 | 30.3 | 3.80 | 0.000661 |
| Tgfbrap1 | 603 | 195 | 3.09 | 0.00172 |
| Nfatc3 | 287 | 121 | 2.37 | 0.00226 |
| Hdac3 | 1080 | 377 | 2.86 | 0.00241 |
| Hdac10 | 60.3 | 19.4 | 3.11 | 0.00378 |
| Acvr2b | 177 | 107 | 1.65 | 0.0308 |
| Endogl1 | 77.5 | 39.1 | 1.98 | 0.0462 |
Abbreviations are: Prl2c3, encoding prolactin family 2, subfamily c, member 3; Prl2c4, prolactin family 2, subfamily c, member 4 ; Prl2c2. prolactin family 2, subfamily c, member 2; Efnb2, ephrin B2; Prl2c5, prolactin family 2, subfamily c, member 5; Grem1, gremlin 1; Ptges3, prostaglandin E synthase 3; Fgf10, fibroblast growth factor 10; Ctf1, cardiotrophin 1; Ccl25, chemokine (C-C motif) ligand 25; Fgf7, fibroblast growth factor 7 or keratinocyte growth factor; Efna4, ephrin A4; Bmper, BMP-binding endothelial regulator; Lefty1, left right determination factor 1; Gdf11, growth differentiation factor 11 (BMP 11); Thbs1, thrombospondin 1; Cx3cl1, chemokine (C-X3-C motif) ligand 1; Sema3a, sema domain, secreted, (semaphorin) 3A; Spp1, secreted phosphoprotein 1, osteopontin; Smad2, MAD homolog 2 (Drosophila); Smad3, MAD homolog 3 (Drosophila); Mapk13, mitogen activated protein kinase 13 (p38); Hdac2, histone deacetylase 2; Trrap, transformation/transcription domain-associated protein; Hdac4, histone deacetylase 4; Mapk11, mitogen-activated protein kinase 11 (p38 δ); Tgfbrap1, transforming growth factor, beta receptor associated protein 1; Nfatc3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; Hdac3, histone deacetylase 3; Hdac10, histone deacetylase 10; Acvr2b, activin receptor IIB; Endogl1, endoglin (CD105);