Table 1.
Microscopic observation on protective and preventive effects of berberine against CCl4-induced acute liver damage in rats (n = 8).
| Group | Fatty degeneration Mean (SD) |
Vacoulisation Mean (SD) |
Nuclei Mean (SD) |
Hepatocyte necrosis Mean (SD) |
Inflammatory cells infiltration Mean (SD) |
Central vein and portal triad Mean (SD) |
Combined score Mean (SD) |
|---|---|---|---|---|---|---|---|
| Normal | 0.6 (0.3) | 0.3 (0.2) | 1.3 (0.3) | 0.5 (0.1) | 0.7 (0.3) | 2.2 (0.6) | 1.2 (0.3) |
| CCl4 | 5.5 (1.2)** | 4.8 (0.4) ** | 0.3 (0.2) ** | 5.7 (1.9) ** | 5.5 (1.5) ** | 0.4 (0.2) ** | 4.7 (0.9)## |
| Post-treated with berberine | |||||||
| 80 mg/kg | 3.2 (1.6) ## | 2.5 (0.7) ## | 1.7 (0.3) ## | 2.2 (0.4) ## | 2.7 (1.1) ## | 1.2 (0.5) ## | 3.0 (1.3) ## |
| 120 mg/kg | 1.7 (1.3)## | 1.8 (0.2) ## | 1.7 (0.5) ## | 1.6 (0.8) ## | 1.8 (0.2) ## | 2.1 (0.6) ## | 1.8 (0.9) ## |
| 160 mg/kg | 1.4 (0.9) ## | 1.2 (0.4) ## | 1.4 (0.4) ## | 1.2 (0.5) ## | 1.1 (0.4) ## | 1.5 (0.8) ## | 1.1 (0.8) ## |
| Pre-treated with berberine | |||||||
| 120 mg/kg | 2.1 (1.3) ## | 2.3 (1.6) ## | 1.0 (0.7) ## | 2.0 (1.4) ## | 1.5 (0.6) ## | 2.5 (0.4) ## | 2.8 (1.4) ## |
**P < 0.001 when compared with normal group; ##P < 0.001 when compared with CCl4 group. The P values higher than 0.001 were denoted after the means.