Table 3.
Seroreactivity of recombinant proteins in sera from TB patients, LTBI and HC
| TB (n = 117) | LTBI (n = 45) | HC (n = 67) | ||||
|---|---|---|---|---|---|---|
| Antigens | No. Positive1 | Sensitivity2 (%) | No. Positive1 | Sensitivity3 (%) | No. Positive1 | Specificity4 (%) |
| PATHOZYME-MYCO IgG | 40 | 34.2 | NT | NT | 1 | 98.5 |
| Rv1985c IgG | 61 | 52.15 | 28 | 62.2% | 2 | 97.0 |
| Rv1985c IgM | 23 | 19.7 | 5 | 11.1% | 2 | 97.0 |
| Rv1985c IgG + IgM | 73 | 62.45 | 29 | 64.4% | 3 | 95.5 |
| Rv1985c+ PATHOZYME-MYCO IgG | 82 | 70.15 | NT | NT | 3 | 95.5 |
1: For 1985c positive sera, defined as cases for which the optical density (OD) generated by the serum was greater than the mean OD of the healthy control sera plus two standard deviations. For PATHOZYME-MYCO IgG positive sera, defined as cases of more than 400 units per ml, which was calculated by extrapolating the OD from the standard curve and multiplying by 100;
2: Percentage of responding patients out of all TB patients tested;
3: Percentage of responding patients out of all LTBI tested;
4: Percentage of true-negative healthy controls out of all healthy control individuals tested;
5: Statistical significance was determined in respect to sensitivity of PATHOZYME-MYCO IgG by McNemar chi-square test, p < 0.01;
NT: not tested.