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. 2010 Sep 16;9:246. doi: 10.1186/1476-4598-9-246

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Copyright ©2010 Chen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HOX11 Binds to and Transcriptionally Modulates Expression of the Cyclin B1 (CCNB1) Promoter. (A) Chromatin immunoprecipitation (ChIP) analysis using an anti-HOX11 antibody of six regions of the CCNB1 promoter region. (B) ChIP analysis of region 5 of the CCNB1 promoter using an anti-HOX11 antibody and an irrelevant antibody control. (C) Promoter-reporter assays to determine HOX11 transactivation of the empty reporter vector (pGL3), the CCNB1 promoter containing the TAAGTG consensus site (CCNB1L-LUC, Long) and the CCNB1 promoter missing the TAAGTG consensus site (CCNB1S-LUC, Short). Each bar represents the fold ratio of luciferase activity between HOX11- and vector alone-transfected cultures for each promoter-reporter construct. The results are representative of three independent experiments.