Table 2.
Fatty acid composition of lymphoblastoid cell lines transfected with the empty vector, in healthy controls and in patients with the Zellweger syndrome.
| Controls | Zellweger syndrome | ||||
|---|---|---|---|---|---|
| Fatty acid | Mean ± SEM | N | Mean ± SEM | N | Statistics |
| 12:0 | 0.13 ± 0.011 | 16 | 0.27 ± 0.049 | 14 | n.s. |
| 14:0 | 2.06 ± 0.122 | 16 | 1.87 ± 0.101 | 14 | n.s. |
| 16:0 | 21.06 ± 0.343 | 16 | 21.58 ± 0.231 | 14 | n.s. |
| 16:1ω9 | 2.21 ± 0.100 | 16 | 2.03 ± 0.070 | 14 | n.s. |
| 16:1ω7 | 1.27 ± 0.082 | 16 | 1.13 ± 0.058 | 14 | n.s. |
| 18:0 | 15.66 ± 0.220 | 16 | 16.91 ± 0.315 | 14 | P < 0.005 |
| 18:1ω9 | 19.29 ± 0.482 | 16 | 17.01 ± 0.761 | 14 | P < 0.05 |
| 18:1ω7 | 7.29 ± 0.190 | 16 | 6.27 ± 0.275 | 14 | P < 0.01 |
| 18:2ω6 | 2.75 ± 0.113 | 16 | 2.42 ± 0.076 | 14 | P < 0.05 |
| 18:3ω6 | 0.09 ± 0.006 | 16 | 0.05 ± 0.015 | 14 | n.s. |
| 18:3ω3 | 0.06 ± 0.008 | 16 | 0.03 ± 0.009 | 14 | n.s. |
| 20:0 | 0.25 ± 0.010 | 16 | 0.27 ± 0.015 | 14 | n.s. |
| 20:1ω6 | 1.45 ± 0.071 | 16 | 1.66 ± 0.182 | 14 | n.s. |
| 20:2ω6 | 0.36 ± 0.017 | 16 | 0.42 ± 0.029 | 14 | n.s. |
| 20:3ω9 | 0.74 ± 0.048 | 16 | 0.65 ± 0.035 | 14 | n.s. |
| 20:3ω6 | 3.21 ± 0.108 | 16 | 2.64 ± 0.142 | 14 | P < 0.005 |
| 20:4ω6 | 7.06 ± 0.328 | 16 | 8.36 ± 0.696 | 14 | n.s. |
| 20:5ω3 | 0.58 ± 0.042 | 16 | 0.49 ± 0.052 | 14 | n.s. |
| 22:0 | 0.32 ± 0.018 | 16 | 0.32 ± 0.022 | 14 | n.s. |
| 22:1ω9 | 0.25 ± 0.023 | 16 | 0.39 ± 0.028 | 14 | P < 0.001 |
| 22:4ω6 | 1.23 ± 0.083 | 16 | 2.15 ± 0.168 | 14 | P < 0.0001 |
| 22:5ω6 | 0.31 ± 0.018 | 16 | 0.25 ± 0.021 | 14 | P < 0.05 |
| 22:5ω3 | 4.2 ± 0.218 | 16 | 4.88 ± 0.233 | 14 | P < 0.005 |
| 22:6ω3 | 4.46 ± 0.173 | 16 | 3.91 ± 0.085 | 14 | P < 0.01 |
| 24:0 | 0.41 ± 0.017 | 16 | 0.48 ± 0.021 | 14 | P < 0.005 |
| 24:1ω9 | 0.94 ± 0.073 | 16 | 0.86 ± 0.078 | 14 | P < 0.005 |
| 26:0 | 0.05 ± 0.009 | 16 | 0.14 ± 0.015 | 14 | P < 0.0001 |
| 26:1ω9 | 0.15 ± 0.020 | 16 | 0.38 ± 0.044 | 14 | P < 0.0001 |
| 24:4ω6 | 0.02 ± 0.007 | 16 | 0.03 ± 0.022 | 13 | n.s. |
| 24:5ω6 | 0.02 ± 0.007 | 16 | 0.14 ± 0.038 | 13 | P < 0.005 |
| 24:5ω3 | 0.02 ± 0.008 | 16 | 0.06 ± 0.023 | 13 | n.s. |
| 24:6ω3 | 0.08 ± 0.014 | 16 | 0.15 ± 0.043 | 13 | n.s. |
| 22:6ω3/22:5ω3 | 1.07 ± 0.020 | 16 | 0.83 ± 0.046 | 14 | P < 0.0001 |
| 22:5ω6/22:4ω6 | 0.28 ± 0.018 | 16 | 0.12 ± 0.011 | 14 | P < 0.0001 |
This table is a list of the mean values ± SEM of total fatty acids (mol%) and their main ratios in human lymphocytes transfected with the empty plasmid (pIRES2EGFP), in normal controls as well as in Zellweger-syndrome patients. P values are only shown for statistically significant changes.