Figure 4.

Quantification of amyloid plaques in APP23 mouse brain in the presence or absence of X11L. Immunostaining of coronal sections of the brain region including the cerebral cortex and hippocampus of APP23 (Fig. 4A, upper panels) and APP23/X11L-Ko mice (Fig. 4B, lower panels) at 12 months of age is shown. The brain sections were stained with anti-Aβ 82E1 antibody to detect human Aβ. Stains indicate amyloid plaque. Bar, 300 μm. The data were analyzed by Student's t test (n = 4 serial sections × 6 individuals respectively; **, p < 0.01). The error bars are S.E.