Table 1.
Effect of X11s in the generation of Aβ in the brains of several transgenic and knock-out mouse lines
| Reference number in text | Authors & Journal | X11 family genes | APP and PS genes | Examination of brain Aβ levels | Effect of X11s in the generation of Aβ |
|---|---|---|---|---|---|
| [10] | Sano et al., J. Biol. Chem. (2006) 281, 37853-37860. |
X11L, knock-out | endogenous mouse APP |
mouse Aβ40 mouse Aβ42 |
suppressive |
| [11] | Saito et al., J. Biol. Chem. (2008) 283, 35763-35771 |
X11, X11L, & X11/X11L, knock-out | endogenous mouse APP |
mouse Aβ40 mouse Aβ42 |
suppressive |
| [15] | Lee et al., J. Biol. Chem. (2003) 278, 47025-47029. |
X11, transgenic | human APPswe transgenic (Tg2576) | human Aβ40 human Aβ42 |
suppressive |
| [16] | Lee et al., J. Biol. Chem. (2004) 279, 49099-49104. |
X11L, transgenic | human APPswe transgenic (Tg2576) | human Aβ40 human Aβ42 |
suppressive |
| [17] | Ho et al., J. Neurosci. (2008) 28, 14392-14400. |
X11, X11L or X11L2, knock-out | human APPswe/PS1dE9 double-transgenic |
human Aβ40 human Aβ42 |
facilitative |
| [23] | Saluja et al., Neurobiol. Dis. (2009) 36, 162-168. |
X11, heterozygous knock-out | human APPswe/PS1dE9 double-transgenic |
human Aβ40 human Aβ42 |
suppressive |
| [24] | Mitchell et al., Hum. Mol. Genet. (2009) 18, 4492-4500. |
X11L, transgenic | human APPswe transgenic (Tg2576) |
human Aβ40 human Aβ42 |
suppressive |
| Present results | Kondo et al., Mol. Neurodegen. |
X11L, knock-out | human APPswe transgenic (APP23), human APPswe transgenic (APP-ibl) |
human Aβ40 human Aβ42 |
suppressive |