Table 1.
#Converging | P-values | Most significant biological process | ||||
---|---|---|---|---|---|---|
SBC | SBC | Prototype | MCS | Malignancy Score | GO | |
SBC1 | 11 | 6 | 9.4 × 10-4 | 1.8 × 10-13 | 5.1 × 10-9 | epidermis development |
SBC2 | 188 | 7 | 1.0 × 10-8 | 7.1 × 10-7 | lipid metabolic process | |
SBC3 | 2 | 1 | 1.5 × 10-6 | 5.5 × 10-8 | 3.2 × 10-32 | immune system process |
SBC4 | 96 | 2 | 1.8 × 10-1 | 2.0 × 10-53 | immune system process | |
SBC5 | 15 | 15 | 1.1 × 10-18 | 7.7 × 10-21 | 1.8 × 10-14 | cell cycle process |
SBC6 | 328 | 11 | 3.0 × 10-7 | 4.9 × 10-8 | 1.8 × 10-20 | multicellular organismal process |
SBC7 | 359 | 229 | 4.0 × 10-14 | -5.4 × 10-22 | 3.2 × 10-22 | gen. of precursor metabolic & energy |
SBC8 | 1 | 1 | 3.0 × 10-10 | -5.2 × 10-8 | 2.2 × 10-2 | lipid metabolic process |
Numerical characterisations and biological relevance of the eight super-biclusters generated by BOA on the gastric cancer data. In the second column of the table, the numbers of biclusters that converged to a particular super-bicluster are given, while the third column is the number of identical biclusters converging to the prototype of that super-bicluster. The columns of "MCS", "Malignancy Score" and "GO" contain the p-values calculated with respect to the prototype of each super-bicluster in terms of the three statistics described in Section 2.3. Note that the negative sign, '-', in the Malignancy Score for SBC7 and SBC8 indicates the significance of agreement with the reverse order.