Table 1.
Gastrin concentrations following cysteamine bitartrate non-enteric-coated and cysteamine bitartrate enteric-coated. Mean gastrin concentrations were calculated from measurements every 30–60 min for 4 h after drug ingestion. Normal gastrin concentrations are <100 pg ml−1. One subject vomited 1 h after receiving cysteamine bitartrate non-enteric-coated 900 mg (gastrin concentration 37 pg ml−1) and 3.5h after receiving cysteamine bitartrate enteric-coated 900 mg (gastrin concentration 29 pg ml−1 at 3 h and 33 pg ml−1 at 4 h)
| Formulation and dosage(number of patients) | Mean gastrin concentration (pg ml−1)(number of specimens) | Standard deviation for gastrin | Cysteamine bitartrate enteric-coated 450 mg(SE) | Cysteamine bitartrate enteric-coated 900 mg(SE) | Cysteamine bitartrate non-enteric-coated 450 mg(SE) | Cysteamine bitartrate non-enteric-coated 900 mg(SE) |
|---|---|---|---|---|---|---|
| Cysteamine bitartrate non-enteric-coated 450 mg (n = 6) | 19.8 (39) | 9.7 | — | **P = 0.01 (2.78) | *P = 0.38 (1.85) | *P = 0.53 (1.83) |
| Cysteamine bitartrate non-enteric-coated 900 mg (n = 2) | 26.2 (14) | 8.1 | — | — | **P = <0.002 (2.77) | **P = 0.0001 (2.75) |
| Cysteamine bitartrate enteric-coated 450 mg (n = 6) | 18.4 (40) | 10.1 | — | — | — | *P = 0.28 (1.82) |
| Cysteamine bitartrate enteric-coated 900 mg (n = 6) | 16.3 (42) | 7.2 | — | — | — | — |
Statistically significant difference in gastrin response between different doses and formulations is ** (P < 0.05) and non-significant is * (P > 0.05). Cysteamine bitartrate enteric-coated and cysteamine bitartrate non-enteric-coated dosages are shown with P values and also standard error (SE) in parenthesis.