Table 1.
Maintenance dose of warfarin by VKORC1 SNPs, stratified by race
| SNP | Major allele (A) | Minor allele (B) | AA (n) | AB (n) | BB (n) | AA Median dose (min−max) | AB Median dose (min−max) | BB Median dose (min−max) | P value* | Partial R2* |
|---|---|---|---|---|---|---|---|---|---|---|
| African American | ||||||||||
| rs17878544 | A | G | 9 | 11 | 2 | 37.50 (10.00–62.50) | 47.50 (25.00–80.00) | 38.75 (30.00–47.50) | 0.53 | 0.02 |
| rs2884737 | A | C | 19 | 2 | 0 | 45.00 (10.00–80.00) | 32.50 (30.00–35.00) | – | † | † |
| rs17708472 | G | A | 19 | 3 | 0 | 45.00 (10.00–80.00) | 35.00 (32.50–50.00) | – | 0.91 | <0.001 |
| rs17886199 | G | A | 18 | 4 | 0 | 46.25 (27.50–80.00) | 25.63 (10.00–37.50) | – | 0.002 | 0.42 |
| rs8050894 | C | G | 13 | 9 | 0 | 37.50 (10.00–67.50) | 45.00 (30.00–80.00) | – | 0.27 | 0.07 |
| rs2359612 | G | A | 15 | 7 | 0 | 47.50 (10.00–80.00) | 35.00 (26.25–62.50) | – | 0.92 | <0.001 |
| rs7200749 | G | A | 14 | 8 | 0 | 41.25 (10.00–80.00) | 40.00 (27.50–67.50) | – | 0.73 | 0.01 |
| rs7294 | T | C | 7 | 9 | 5 | 52.50 (27.50–67.50) | 45.00 (25.00–62.50) | 37.50 (10.00–80.00) | 0.28 | 0.07 |
| rs7199949 | G | C | 8 | 9 | 5 | 50.00 (27.50–67.50) | 45.00 (25.00–80.00) | 32.50 (10.00–37.50) | 0.07 | 0.18 |
| Caucasian | ||||||||||
| rs17878544 | A | G | 35 | 1 | 0 | 37.50 (17.50–95.00) | 42.50 | – | – | – |
| rs2884737 | A | C | 22 | 10 | 3 | 43.75 (22.00–80.00) | 30.00 (17.50–95.00) | 22.50 (20.00–23.00) | 0.36 | 0.02 |
| rs17708472 | G | A | 28 | 8 | 0 | 36.75 (17.50–95.00) | 42.25 (22.00–56.25) | – | 0.69 | 0.003 |
| rs17886199 | G | A | 34 | 0 | 0 | 36.75 (17.50–95.00) | – | – | – | – |
| rs8050894 | C | G | 16 | 16 | 4 | 52.50 (25.00–80.00) | 30.00 (17.50–95.00) | 22.75 (20.00–26.00) | 0.10 | 0.05 |
| rs2359612 | G | A | 16 | 14 | 6 | 47.50 (25.00–80.00) | 28.75 (17.50–95.00) | 24.50 (20.00–55.00) | 0.46 | 0.01 |
| rs7200749 | G | A | 34 | 1 | 0 | 36.75 (17.50–95.00) | 42.50 | – | – | – |
| rs7294 | T | C | 12 | 13 | 6 | 47.50 (27.50–80.00) | 35.00 (17.50–95.00) | 28.00 (22.00–52.50) | 0.20 | 0.03 |
| rs7199949 | G | C | 11 | 15 | 10 | 45.00 (25.00–80.00) | 35.00 (17.50–95.00) | 28.00 (20.00–55.00) | 0.85 | <0.001 |
*
The relationship between each SNP and log-transformed maintenance dose was adjusted for the VKORC1 1173C>T and CYP2C9*2 and *3 variants.
†
The VKORC1 1173C>T and rs2884737A>C were in complete linkage disequilibrium. Therefore, we could not run the statistical analyses.