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. 2010 Sep;70(3):393–399. doi: 10.1111/j.1365-2125.2010.03709.x

Table 1.

Maintenance dose of warfarin by VKORC1 SNPs, stratified by race

SNP Major allele (A) Minor allele (B) AA (n) AB (n) BB (n) AA Median dose (min−max) AB Median dose (min−max) BB Median dose (min−max) P value* Partial R2*
African American
rs17878544 A G 9 11 2 37.50 (10.00–62.50) 47.50 (25.00–80.00) 38.75 (30.00–47.50) 0.53 0.02
rs2884737 A C 19 2 0 45.00 (10.00–80.00) 32.50 (30.00–35.00)
rs17708472 G A 19 3 0 45.00 (10.00–80.00) 35.00 (32.50–50.00) 0.91 <0.001
rs17886199 G A 18 4 0 46.25 (27.50–80.00) 25.63 (10.00–37.50) 0.002 0.42
rs8050894 C G 13 9 0 37.50 (10.00–67.50) 45.00 (30.00–80.00) 0.27 0.07
rs2359612 G A 15 7 0 47.50 (10.00–80.00) 35.00 (26.25–62.50) 0.92 <0.001
rs7200749 G A 14 8 0 41.25 (10.00–80.00) 40.00 (27.50–67.50) 0.73 0.01
rs7294 T C 7 9 5 52.50 (27.50–67.50) 45.00 (25.00–62.50) 37.50 (10.00–80.00) 0.28 0.07
rs7199949 G C 8 9 5 50.00 (27.50–67.50) 45.00 (25.00–80.00) 32.50 (10.00–37.50) 0.07 0.18
Caucasian
rs17878544 A G 35 1 0 37.50 (17.50–95.00) 42.50
rs2884737 A C 22 10 3 43.75 (22.00–80.00) 30.00 (17.50–95.00) 22.50 (20.00–23.00) 0.36 0.02
rs17708472 G A 28 8 0 36.75 (17.50–95.00) 42.25 (22.00–56.25) 0.69 0.003
rs17886199 G A 34 0 0 36.75 (17.50–95.00)
rs8050894 C G 16 16 4 52.50 (25.00–80.00) 30.00 (17.50–95.00) 22.75 (20.00–26.00) 0.10 0.05
rs2359612 G A 16 14 6 47.50 (25.00–80.00) 28.75 (17.50–95.00) 24.50 (20.00–55.00) 0.46 0.01
rs7200749 G A 34 1 0 36.75 (17.50–95.00) 42.50
rs7294 T C 12 13 6 47.50 (27.50–80.00) 35.00 (17.50–95.00) 28.00 (22.00–52.50) 0.20 0.03
rs7199949 G C 11 15 10 45.00 (25.00–80.00) 35.00 (17.50–95.00) 28.00 (20.00–55.00) 0.85 <0.001
*

The relationship between each SNP and log-transformed maintenance dose was adjusted for the VKORC1 1173C>T and CYP2C9*2 and *3 variants.

The VKORC1 1173C>T and rs2884737A>C were in complete linkage disequilibrium. Therefore, we could not run the statistical analyses.