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. 2010 Sep;70(3):393–399. doi: 10.1111/j.1365-2125.2010.03709.x

Table 3.

Maintenance dose of warfarin by GGCX SNPs, stratified by race

SNP Major allele (A) Minor allele (B) AA (n) AB (n) BB (n) AA Median dose (min−max) AB Median dose (min−max) BB Median dose (min−max) P value* Partial R2*
African American
rs7568458 A T 10 11 1 41.25 (10.00–67.50) 45.00 (25.00–80.00) 35.00 0.58 0.02
rs6751560 G A 18 4 0 40.00 (10.00–80.00) 43.75 (26.25–52.50) 0.96 <0.001
rs17026452 G C 18 3 1 40.00 (10.00–80.00) 37.50 (26.25–50.00) 52.50 0.78 0.005
rs699664 C T 2 10 10 48.75 (35.00–62.50) 40.00 (25.00–80.00) 41.25 (10.00–67.50) 0.44 0.04
rs2592551 G A 5 12 5 35.00 (26.25–62.50) 45.00 (25.00–80.00) 32.50 (10.00–67.50) 0.55 0.02
rs10179904 G A 20 2 0 41.25 (10.00–80.00) 36.25 (27.50–45.00) 0.71 0.01
rs11676382 C G 22 0 0 41.25 (10.00–80.00)
rs17026447 A C 20 1 0 41.25 (10.00–80.00) 52.50
Caucasian
rs7568458 A T 6 18 12 32.75 (20.00–55.00) 36.75 (17.50–80.00) 40.63 (17.50–95.00) 0.93 <0.001
rs6751560 G A 33 3 0 37.50 (17.50–95.00) 42.50 (23.00–50.00)
rs17026452 G C 30 4 1 38.75 (17.50–95.00) 28.75 (23.00–42.50) 50.00 0.38 0.02
rs699664 C T 12 22 2 40.63 (17.50–95.00) 36.75 (17.50–80.00) 36.25 (22.50–50.00) 0.84 <0.001
rs2592551 G A 15 20 1 40.00 (17.50–95.00) 38.75 (17.50–80.00) 22.50 0.64 0.005
rs10179904 G A 33 3 0 37.50 (17.50–95.00) 42.50 (20.00–55.00)
rs11676382 C G 32 4 0 36.75 (17.50–95.00) 41.63 (27.50–42.50) 0.84 <0.001
rs17026447 A C 31 5 0 37.50 (17.50–95.00) 42.50 (27.50–55.00) 0.31 0.02
*

The relationship between each SNP and log-transformed maintenance dose was adjusted for the VKORC1 1173C>T and CYP2C9*2 and *3 variants.