Table 3.
Lung Cancer Risk Estimates by Gamma-radiation-induced G2/M Arrest
| G2/M arrest | Cases | Controls | OR 1 (95%CI) | OR2 (95%CI) |
|---|---|---|---|---|
| Overall | ||||
| Above median | 133 | 275 | 1.00 | 1.00 |
| Below median | 166 | 275 | 1.22 (0.91–1.64) | 1.01 (0.69–1.47) |
| By quartiles | ||||
| 4th quartile | 66 | 142 | 1.00 | 1.00 |
| 3rd quartile | 67 | 133 | 0.98 (0.64–1.52) | 0.86 (0.53–1.39) |
| 2nd quartile | 63 | 136 | 0.97 (0.63–1.51) | 0.80 (0.47–1.36) |
| 1st quartile | 103 | 139 | 1.43 (0.95–2.15) | 1.08 (0.59–1.96) |
| Ptrend | 0.08 | 0.73 | ||
| Males | ||||
| Above median | 65 | 124 | 1.00 | 1.00 |
| Below median | 79 | 149 | 0.99 (0.64–1.52) | 0.83 (0.48–1.44) |
| By quartiles | ||||
| 4th quartile | 32 | 54 | 1.00 | 1.00 |
| 3rd quartile | 33 | 70 | 0.77 (0.41–1.45) | 0.63 (0.32–1.27) |
| 2nd quartile | 31 | 69 | 0.80 (0.42–1.51) | 0.60 (0.28–1.28) |
| 1st quartile | 48 | 80 | 0.91 (0.50–1.66) | 0.58 (0.24–1.41) |
| Ptrend | ||||
| Females | ||||
| Above median | 68 | 151 | 1.00 | 1.00 |
| Below median | 87 | 126 | 1.44 (0.95–2.18) | 1.19 (0.70–2.04) |
| By quartiles | ||||
| 4th quartile | 34 | 88 | 1.00 | 1.00 |
| 3rd quartile | 34 | 63 | 1.16 (0.63–2.12) | 1.09 (0.55–2.14) |
| 2nd quartile | 32 | 67 | 1.08 (0.59–2.00) | 0.99 (0.47–2.09) |
| 1st quartile | 55 | 59 | 2.03 (1.15–3.57) | 1.79 (0.78–4.08) |
| Ptrend | 0.02 | 0.17 | ||
| African Americans | ||||
| Above median | 36 | 126 | 1.00 | 1.00 |
| Below median | 45 | 95 | 1.58 (0.90–2.77) | 1.64 (0.81–3.33) |
| By quartiles | ||||
| 4th quartile | 18 | 69 | 1.00 | 1.00 |
| 3rd quartile | 18 | 57 | 0.83 (0.36–1.92) | 0.96 (0.38–2.39) |
| 2nd quartile | 17 | 53 | 0.93 (0.41–2.09) | 1.14 (0.43–3.03) |
| 1st quartile | 28 | 42 | 2.16 (1.00–4.64) | 2.97 (0.96–9.19) |
| Ptrend | 0.05 | 0.05 | ||
| African American/Males | ||||
| Above median | 18 | 55 | 1.00 | 1.00 |
| Below median | 20 | 48 | 1.16 (0.52–2.59) | 0.95 (0.35–2.61) |
| By quartiles | ||||
| 4th quartile | 9 | 24 | 1.00 | 1.00 |
| 3rd quartile | 9 | 31 | 0.67 (0.21–2.17) | 0.57 (0.16–1.99) |
| 2nd quartile | 9 | 24 | 0.79 (0.25–2.51) | 0.60 (0.15–2.35) |
| 1st quartile | 11 | 24 | 1.13 (0.37–3.44) | 0.74 (0.15–3.58) |
| Ptrend | 0.75 | 0.78 | ||
| African American/Females | ||||
| Above median | 18 | 71 | 1.00 | 1.00 |
| Below median | 25 | 47 | 2.02 (0.91–4.49) | 2.63 (1.01–7.26) |
| By quartiles | ||||
| 4th quartile | 9 | 45 | 1.00 | 1.00 |
| 3rd quartile | 9 | 26 | 0.92 (0.27–3.15) | 1.76 (0.43–7.18) |
| 2nd quartile | 8 | 29 | 1.00 (0.32–3.19) | 2.24 (0.54–9.33) |
| 1st quartile | 17 | 18 | 3.61 (1.23–10.61) | 13.72 (2.30–81.92) |
| Ptrend | 0.03 | <0.01 | ||
| Caucasians | ||||
| Above median | 97 | 149 | 1.00 | 1.00 |
| Below median | 121 | 180 | 1.09 (0.77–1.56) | 0.82 (0.52–1.29) |
| By quartiles | ||||
| 4th quartile | 48 | 73 | 1.00 | 1.00 |
| 3rd quartile | 49 | 76 | 0.98 (0.58–1.65) | 0.76 (0.42–1.36) |
| 2nd quartile | 46 | 83 | 0.93 (0.55–1.58) | 0.64 (0.34–1.22) |
| 1st quartile | 75 | 97 | 1.20 (0.74–1.95) | 0.70 (0.34–1.44) |
| Ptrend | 0.46 | 0.41 | ||
| Caucasian/Males | ||||
| Above median | 47 | 69 | 1.00 | 1.00 |
| Below median | 59 | 101 | 0.91 (0.55–1.52) | 0.77 (0.40–1.49) |
| By quartiles | ||||
| 4th quartile | 23 | 30 | 1.00 | 1.00 |
| 3rd quartile | 24 | 39 | 0.80 (0.37–1.73) | 0.66 (0.28–1.54) |
| 2nd quartile | 22 | 45 | 0.75 (0.34–1.63) | 0.57 (0.22–1.44) |
| 1st quartile | 37 | 56 | 0.85 (0.41–1.74) | 0.55 (0.19–1.62) |
| Ptrend | 0.72 | 0.33 | ||
| Caucasian/Females | ||||
| Above median | 50 | 80 | 1.00 | 1.00 |
| Below median | 62 | 79 | 1.28 (0.78–2.12) | 0.88 (0.46–1.68) |
| By quartiles | ||||
| 4th quartile | 25 | 43 | 1.00 | 1.00 |
| 3rd quartile | 25 | 37 | 1.11(0.54–2.28) | 0.81 (0.36–1.82) |
| 2nd quartile | 24 | 38 | 1.11 (0.53–2.35) | 0.71 (0.28–1.77) |
| 1st quartile | 38 | 41 | 1.54 (0.78–3.03) | 0.83 (0.31–2.22) |
| Ptrend | 0.22 | 0.75 | ||
OR1: adjusted for age, pack-years, gender and race (where appropriate)
OR2: adjusted for baseline mitotic index, age, pack-years, gender and race (where appropriate)