Table 4.
Mean Percent of Gamma-radiation-induced G2/M Arrest by Genotypes in Controls
| Genotype | N | Mean (SD) | P† | Genotype | N | Mean (SD) | P† |
|---|---|---|---|---|---|---|---|
| ATM Ex1-81G>A | TP53 1474bp 3′ of STP C>T | ||||||
| GG | 132 | 1.62 (0.86) | CC | 155 | 1.51 (0.90) | ||
| GA | 214 | 1.38 (0.81) | 0.01 | CT | 165 | 1.51 (0.72) | 0.96 |
| AA | 100 | 1.33 (0.74) | 0.01 | TT | 67 | 1.24 (0.77) | 0.02 |
| GA+AA | 314 | 1.36 (0.79) | 0.03 | CT+TT | 232 | 1.38 (0.73) | 0.03 |
| ATM D126E | CDKN1A S31R | ||||||
| TT | 396 | 1.43 (0.79) | CC | 408 | 1.39 (0.81) | ||
| TA | 56 | 1.54 (0.88) | 0.29 | CA | 99 | 1.50 (0.85) | 0.22 |
| AA | 4 | 2.63 (0.24) | 0.01 | AA | 16 | 1.86 (0.93) | 0.02 |
| TA+AA | 60 | 1.62 (0.89) | 0.09 | CA+AA | 115 | 1.55 (0.87) | 0.06 |
| BRCA2 N372H | CDC25C Ex1-62T>G | ||||||
| AA | 308 | 1.48 (0.81) | TT | 317 | 1.48 (0.81) | ||
| AC | 181 | 1.36 (0.82) | 0.11 | TG | 69 | 1.20 (0.80) | 0.01 |
| CC | 29 | 1.11 (0.90) | 0.02 | GG | 5 | 1.38 (0.71) | 0.80 |
| AC+CC | 210 | 1.23 (0.83) | 0.03 | TG+GG | 74 | 1.22 (0.79) | 0.01 |
| ERCC6 M1097V | TP53BP1 IVS4+703G>T | ||||||
| AA | 300 | 1.44 (0.80) | GG | 140 | 1.33 (0.85) | ||
| AG | 135 | 1.51 (0.80) | 0.38 | GT | 168 | 1.43 (0.79) | 0.27 |
| GG | 21 | 1.41 (0.71) | 0.90 | TT | 151 | 1.58 (0.78) | 0.01 |
| AG+GG | 156 | 1.46 (0.80) | 0.41 | GT+TT | 319 | 1.50 (0.78) | 0.04 |
| ERCC6 Q1413R | TP53BP1 IVS16+36T>C | ||||||
| AA | 303 | 1.43 (0.81) | TT | 295 | 1.44 (0.81) | ||
| AG | 130 | 1.5 (0.85) | 0.45 | TC | 141 | 1.46 (0.80) | 0.63 |
| GG | 21 | 1.4 (0.75) | 0.86 | CC | 10 | 1.34 (0.73) | 0.68 |
| AG+GG | 151 | 1.48 (0.83) | 0.51 | TC+CC | 151 | 1.38 (0.72) | 0.81 |
| ERCC6 R1213G | TP53BP1 IVS1+544G>A | ||||||
| AA | 294 | 1.43 (0.80) | GG | 143 | 1.35 (0.87) | ||
| AG | 142 | 1.50 (0.82) | 0.40 | GA | 179 | 1.42 (0.79) | 0.07 |
| GG | 23 | 1.39 (0.71) | 0.84 | AA | 138 | 1.58 (0.76) | 0.02 |
| AG+GG | 165 | 1.48 (0.81) | 0.52 | GA+AA | 317 | 1.48 (0.79) | 0.02 |
| GADD45A Ex1+16A>T | TP53BP1 IVS2 + 7G>A | ||||||
| TT | 464 | 1.41 (0.81) | GG | 259 | 1.40 (0.84) | ||
| TA | 42 | 1.61 (0.72) | 0.11 | GA | 135 | 1.46 (0.78) | 0.22 |
| AA | 7 | 0.99 (1.04) | 0.16 | AA | 66 | 1.63 (0.77) | 0.04 |
| TA+AA | 49 | 1.52 (0.79) | 0.32 | GA+AA | 201 | 1.55 (0.82) | 0.04 |
| TP53 P72R | TP53BP1 D353E | ||||||
| GG | 238 | 1.40 (0.82) | CC | 141 | 1.34 (0.85) | ||
| GC | 206 | 1.41 (0.82) | 0.27 | CG | 168 | 1.42 (0.79) | 0.30 |
| CC | 82 | 1.53 (0.78) | 0.21 | GG | 152 | 1.57 (0.78) | 0.01 |
| GC+CC | 288 | 1.47 (0.82) | 0.20 | CG+GG | 320 | 1.49 (0.79) | 0.06 |
†
p-values are comparing the means between wild-type homozygote group and heterozygote group or variant homozygote group or combined heterozygote and variant homozygote group.
Notes: None of the other 32 SNPs that were examined (see supplementary Table 1) showed any significant associations with G2/M arrest phenotype