Table 5.
Estimates of Association between Gamma-radiation-induced G2/M Arrest and Genotypes among Controls
| Genotype | G2/M arrest high/low | OR(95%CI) | Genotype | G2/M arrest high/low | OR(95%CI) |
|---|---|---|---|---|---|
| ATM Ex1-81G>A | TP53 1474bp 3′ of STP C>T | ||||
| GG | 79/53 | 1.00 | CC | 90/65 | 1.00 |
| GA | 110/104 | 1.09 (0.58–2.03) | CT | 101/64 | 0.64 (0.36–1.16) |
| AA | 51/49 | 0.95 (0.45–2.04) | TT | 31/36 | 1.07 (0.5–2.27) |
| GA+AA | 161/153 | 0.98 (0.67–1.43) | CT+TT | 132/100 | 0.75 (0.43–1.30) |
| ATM D126E | CDKN1A S31R | ||||
| TT | 212/184 | 1.00 | CC | 208/200 | 1.00 |
| TA | 33/23 | 1.16 (0.48–2.88) | CA | 56/43 | 1.12 (0.62–2.05) |
| AA | 4/0 | - | AA | 13/3 | 0.66 (0.14–3.1) |
| TA+AA | 37/23 | 1.05 (0.46–2.38) | CA+AA | 69/46 | 0.84 (0.51–1.37) |
| BRCA2 N372H | CDC25C Ex1-62T>G | ||||
| AA | 174/134 | 1.00 | TT | 185/132 | 1.00 |
| AC | 88/93 | 0.98 (0.59–1.62) | TG | 29/40 | 0.80 (0.39–1.69) |
| CC | 12/17 | 0.75 (0.26–2.21) | GG | 3/2 | 0.65 (0.04–10.3) |
| AC+CC | 100/110 | 0.93 (0.62–1.38) | TG+GG | 32/42 | 1.15 (0.59–2.22) |
| ERCC6 M1097V | TP53BP1 IVS4+703G>T | ||||
| AA | 153/147 | 1.00 | GG | 66/74 | 1.00 |
| AG | 87/48 | 0.32 (0.18–0.58) | GT | 88/80 | 0.99 (0.53–1.85) |
| GG | 10/11 | 1.09 (0.34–3.51) | TT | 95/56 | 0.62 (0.31–1.28) |
| AG+GG | 97/59 | 0.56 (0.36–0.88) | GT+TT | 183/136 | 0.81 (0.54–1.24) |
| ERCC6 Q1413R | TP53BP1 IVS16+36T>C | ||||
| AA | 154/149 | 1.00 | TT | 156/139 | 1.00 |
| AG | 82/48 | 0.36 (0.2–0.65) | TC | 79/62 | 0.90 (0.53–1.54) |
| GG | 10/11 | 0.95 (0.28–3.18) | CC | 5/5 | 1.98 (0.37–10.49) |
| AG+GG | 92/59 | 0.57 (0.36–0.89) | TC+CC | 84/67 | 0.95 (0.56–1.60) |
| ERCC6 R1213G | TP53BP1 IVS1+544G>A | ||||
| AA | 148/146 | 1.00 | GG | 68/75 | 1.00 |
| AG | 90/52 | 0.38 (0.22–0.67) | GA | 94/85 | 0.91 (0.49–1.69) |
| GG | 11/12 | 0.92 (0.29–2.86) | AA | 87/51 | 0.62 (0.27–1.43) |
| AG+GG | 101/64 | 0.59 (0.38–0.91) | GA+AA | 181/136 | 0.85 (0.46–1.56) |
| GADD45A Ex1+16A>T | TP53BP1 IVS2 +7G>A | ||||
| TT | 243/221 | 1.00 | GG | 122/137 | 1.00 |
| TA | 28/14 | 0.94 (0.36–2.46) | GA | 74/61 | 0.99 (0.53–1.85) |
| AA | 2/5 | 6.45 (0.87–48.04) | AA | 42/24 | 0.62 (0.31–1.28) |
| TA+AA | 30/19 | 1.28 (0.53–3.11) | GA+AA | 116/85 | 0.81 (0.54–1.24) |
| TP53 P72R | TP53BP1 D353E | ||||
| GG | 125/113 | 1.00 | CC | 67/74 | 1.00 |
| GC | 111/95 | 1.19 (0.70–2.00) | CG | 87/81 | 0.95 (0.31–1.77) |
| CC | 45/37 | 1.27 (0.62–2.60) | GG | 95/57 | 0.62 (0.30–1.26) |
| GC+CC | 156/132 | 1.21 (0.74–1.98) | CG+GG | 182/138 | 0.83 (0.55–1.26) |
ORs are adjusted for age, gender, race, pack-years and baseline mitotic index
None of the other 32 SNPs that were examined (see supplementary Table 1) showed any significant association with G2/M arrest phenotype