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. 2010 Jun 16;2:43. doi: 10.3410/M2-43

Figure 2. Effect of glucose and glucokinase activator (GKA) binding on the configuration of the allosteric activator site of glucokinase (GK).

Figure 2.

A critical cutout of the GK structure is presented to show the conformational change induced by glucose allowing GKA to bind. Note the marked rearrangement of known contact amino acids in the drug receptor region of the enzyme. Based on structures reported by Kamata et al. [13].