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. 2010 Jul;30(7):513–523. doi: 10.1089/jir.2009.0105

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Copyright 2010, Mary Ann Liebert, Inc.

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FIG. 2. — Oncostatin M (OSM) expression in renal tissue. (A and B) Immunohistochemistry of OSM in human kidney. Immunostain shows strong expression of OSM in atrophic tubular cells, glomerular cells, and interstitial inflammatory cells in a representative kidney with obstructive nephropathy (B). Only weak, focal expression of OSM is noted in a representative normal kidney (A). Original magnification: 200×. (C–F) Immunohistochemistry of OSM in control normal kidneys of rats (C), and obstructed kidneys at 12 h (D) and 24 h (E) after UUO. Increased expression of OSM is evident in renal tubular cells of the obstructed kidneys. Control IgG shows no staining for OSM (F). The results are representative of kidneys derived from 3 different animals. Original magnification: 200×.