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. Author manuscript; available in PMC: 2011 Sep 21.
Published in final edited form as: Sci Signal. 2010 Sep 21;3(140):ra67. doi: 10.1126/scisignal.2001083

Table 1. Validated EGFR-sensitizing genes.

Validated screen hits. Symbol is the official Entrez gene name, ID is Entrez gene ID.

Symbol ID Gene Description Origin Clinical agent
ABL1 25 v-abl Abelson murine leukemia viral oncogene homolog 1 PPI1 Imatinib, dasatinib
AKT2 208 v-akt murine thymoma viral oncogene homolog 2 PG Perifosine, triciribine, GSK690693
ANXA6 309 annexin A6 C, PPI2
ARF4 378 ADP-ribosylation factor 4 PM, PPI1
ARF5 381 ADP-ribosylation factor 5 PG
ASCL2 430 achaete-scute complex homolog 2 (Drosophila) PPI2, DG
BCAR1 9564 breast cancer anti-estrogen resistance 1 PM, C, PPI1
CALM1 801 calmodulin 1 (phosphorylase kinase, delta) C PPI1 phenothiazines
CBLC 23624 Cas-Br-M (murine) ecotropic retroviral transforming sequence c PM PPI1
CCND1 595 cyclin D1 PM, PPI2
CD59 966 CD59 molecule, complement regulatory protein C, PPI2 Roche, Preclinical
CDH3 1001 cadherin 3, type 1, P-cadherin (placental) PG
CXCL12 6387 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) MA
DCN 1634 decorin PPI1
DDR2 4921 discoidin domain receptor family, member 2 PPI1
DIXDC1 85458 DIX domain containing 1 MA
DLG4 1742 discs, large homolog 4 (Drosophila) PPI1
DUSP4 1846 dual specificity phosphatase 4 MA
DUSP6 1848 dual specificity phosphatase 6 DG
DUSP7 1849 dual specificity phosphatase 7 DG
EPHA5 2044 EPH receptor A5 PG
ERBB3 2065 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PM, PPI1, DG antibodies, for example MM-121
FER 2241 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) PPI1
FGFR2 2263 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) DG For example, brivanib, masitinib, TKI258, PHA-739358
FLNA 2316 filamin PG, alpha (actin binding protein 280) C, PPI2
GRB7 2886 growth factor receptor-bound protein 7 PM, PPI1
HSPA9 3313 heat shock 70kDa protein 9 (mortalin) C, PPI2
INPPL1 3636 inositol polyphosphate phosphatase-like 1 PM, PPI1
KLF10 7071 Kruppel-like factor 10 MA
LOC284393 284393 similar to ribosomal protein L10 PG
LOC63920 63920 transposon-derived Buster3 transposase-like MA
LTK 4058 leukocyte tyrosine kinase PPI1
MAP3K1 4214 mitogen-activated protein kinase kinase kinase 1 PM, PPI2
MAPK1 5594 mitogen-activated protein kinase 1 PM, PPI1
MATK 4145 megakaryocyte-associated tyrosine kinase PM, PPI1
NEDD9 4739 neural precursor cell expressed, developmentally down-regulated 9 PPI1
NOTCH2 4853 notch 2 DG
PIK3R1 5295 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) PM, PPI1 For example, PX-866, BGT226, GDC-0941, XL765
PIK3R2 5296 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) PM, PPI1
PIN1 5300 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 PM
PKN2 5586 protein kinase N2 PM, PPI2
PLSCR1 5359 phospholipid scramblase 1 PM, PPI1, MA
PPIA 5478 peptidylprolyl isomerase PG (cyclophilin PG) C, PPI2
PRKACB 5567 protein kinase, cAMP-dependent, catalytic, beta PG
PRKCD 5580 protein kinase C, delta PM, PPI1 ruboxistaurin, enzastaurin, tamoxifen
PRKCE 5581 protein kinase C, epsilon PM, PPI2
PRKCZ 5590 protein kinase C, zeta PM, PPI2
PTPRF 5792 protein tyrosine phosphatase, receptor type, F nexin-II, Alzheimer disease) PPI1
RAC1 5879 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) PM, PPI2
RAPGEF1 2889 Rap guanine nucleotide exchange factor (GEF) 1 PPI1
RASA3 22821 RAS p21 protein activator 3 DG
RET 5979 ret proto-oncogene PPI1, M2 valdetanib
RPS6KA5 9252 ribosomal protein S6 kinase, 90kDa, polypeptide 5 PM ruboxistaurin
SC4MOL 6307 sterol-C4-methyl oxidase-like MA
SH2D3C 10044 SH2 domain containing 3C PM, PPI1
SHC1 6464 SHC (Src homology 2 domain containing) transforming protein 1 PM, C, PPI1, DG
SMAD2 4087 SMAD family member 2 PM, PPI1 peptide 144 targets TGFβ1RIII
SOS2 6655 son of sevenless homolog 2 (Drosophila) PM, PPI1, DG
STAT3 6774 signal transducer and activator of transcription PM, C, PPI1 STAT 3 decoy oligonucleotide
TBL1Y 90665 3 (acute-phase response factor) transducin (beta)-like 1Y-linked DG
VAV3 10451 vav 3 oncogene PM, C, PPI1

Hits are listed alphabetically by Gene Symbol (Symbol). Entrez Gene ID (ID), description (including alternative common names), reason for inclusion in the library (Origin), and existence of any targeted small molecule agent (Clinical Agent) are also provided. C, found in a protein complex with seeds; DG, identified from Drosophila genetics; MA, microarray indicates transcriptionally responsive to EGFR; PG, paralog; PM, present in pathway maps; PPI1, direct protein interactions with seeds; PPI2, direct protein interactions with a protein within the PPI1 group.

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