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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2010 Jun 15;18(14):4873–4878. doi: 10.1016/j.bmc.2010.06.028

Figure 3.

Figure 3

Overall (a) and zoom-in (b) view of hCA II – sulfonamide 1 adduct, superposed onto acetazolamide (AZA) one (PDB accession code 3hs4)7c. Note the two compounds follow the same trajectory out of the active site with the extended coumarin heterocycle ring at an angle to the benzene ring with an edge-to-face interaction with the side chain of Phe131. hCA II is depicted as a surface representation (bulk solvent accessible area, light pink; hydrophilic and hydrophobic regions of the active site, blue and orange respectively). Compound 1 and AZA are represented as sticks. Compounds 1 (grey) and AZA (yellow) are represented as sticks. Non-carbon atoms of both compounds are colored as in Figure 1. Figure made using PyMOL (DeLano Scientific).