Table 1.

Inhibition of human α-CAs and Plasmodium falciparum enzymes (hCA and pfCA) with sulfonamides 1-5, by a stopped-flow CO₂ hydrase assay.¹⁷ Data for AZA are from ref.3 whereas data against pfCA from ref.14

Inhibitor	KI (nM)#
	hCA Ia	hCA IIa	hCA IXb	hCA XIIb	pfCAc
1	73	9	87	63	970
2	94	16	59	55	3506
3	131	79	113	128	4580
4	91	12	91	78	1440
5	120	36	14	6	2520
AZA	250	12	25	2.5	315

^#Errors in the range of ± 5 % of the reported data from three different assays by a stopped-flow CO₂ hydration method.¹⁷

^aCytosolic, recombinant enzyme

^bCatalytic domain, recombinant enzyme

^cFrom ref.14