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. 2010 Jul 28;30(30):10187–10198. doi: 10.1523/JNEUROSCI.2268-10.2010

Figure 8.

Figure 8.

Inhibition of NR2B-NMDARs or Src PTKs in the DMS but not in the DLS decreases operant ethanol self-administration. Rats were infused with the NR2B-NMDAR antagonist ifenprodil (Ifen, 0.5 and 2.5 μg/μl/side), the Src PTK inhibitor PP2 (0.3 and 1.5 ng/μl/side) or vehicle (Veh) 15 min before the beginning of the test session in the DMS (A–D) or in the DLS (E, F). A, E, Mean ± SEM of the number of ethanol deliveries during a 30 min session. n = 6–7. *p < 0.05 versus Veh. B, F, Mean ± SEM of the number of ethanol intake (in grams per kilogram) in rats trained on an FR3 schedule to obtain 0.1 ml of a 20% ethanol solution per delivery during 30 min sessions in A and E, respectively. n = 6–7. *p < 0.05 versus Veh. C, Mean ± SEM of the number of sucrose deliveries during a 30 min session. n = 8. D, Mean ± SEM of the number of deliveries in rats trained on an FR3 schedule to obtain 0.1 ml of a 2.5% sucrose solution per delivery during 30 min sessions in C. n = 8.