Figure 9.

Inhibition of NR2B-NMDARs or Src PTKs in the DMS reduces ethanol-priming-induced reinstatement of ethanol seeking. Ifenprodil (2.5 μg/μl/side), PP2 (1.5 ng/μl/side), or vehicle was infused 15 min before the beginning of the test session. A, Mean ± SEM of the number of presses during a 30 min test in extinction. n = 7. B, Mean ± SEM of latency in seconds to the third press (first reward) during the final extinction session and the reinstatement test. C, Mean ± SEM of the number of presses during the final extinction session and reinstatement of ethanol seeking induced by an oral ethanol prime. B, C, n = 8. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus extinction *p < 0.05, **p < 0.01, treatment versus Veh.