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. Author manuscript; available in PMC: 2010 Oct 5.
Published in final edited form as: Alcohol Clin Exp Res. 2009 Apr 9;33(7):1220–1230. doi: 10.1111/j.1530-0277.2009.00946.x

Fig. 6.

Fig. 6

iNOS inhibitors prevented EtOH-induced steatohepatitis. EtOH-induced inflammatory reactions were determined by measuring hepatic myeloperoxidase (MPO) activity (a) and by calculating histological inflammatory scores (b). Total histological score represents a combined inflammatory score (i.e. hepatitis) and score for the severity of fat accumulation in the liver (i.e. steatosis) and thus it represents the severity of steatohepatitis (c). EtOH-induced fatty liver was determined by measuring hepatic fat content (d). Feeding of alcohol to rats for 10 weeks significantly increased MPO activity, inflammation score, histology score, and fat content in liver tissue. iNOS inhibitors (L-NIL or L-NAME) significantly decreased all indices of alcoholic steatohepatitis. Data are expressed as mean ± S.E. for N=6 rats for each group. The difference between groups was analyzed using ANOVA, *: p<0.05 compared to dextrose-fed rats (controls), #: p<0.05 compared to alcohol-fed rats (10 weeks).