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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Magn Reson Med. 2010 Oct;64(4):995–1004. doi: 10.1002/mrm.22411

FIG. 5.

FIG. 5

The duration of BBB disruption was demonstrated by assaying BBB permeability at several times after BOMUS. A separate animal was used to assay each time point. Signal measurements were made in several ROIs from T1-weighted images (high-throughput protocol). To account for inter-animal variability, the muscle signal was used to normalize the intracranial signals: log2 (tissue signal/muscle signal) is plotted along the y-axis. For comparison, data from an untreated control animal is shown at time < 0.