FIG. 8.

T1 values were estimated from three ROIs in control and treated mice (1 mouse per group). In the control animal receiving neither Gd-DTPA nor BOMUS, T1 values were long in the cortex (2.08 s), basal ganglia (1.97 s), and muscle (2.01 s). The animal given only Gd-DTPA had somewhat shortened T1 values in the cortex (1.53 s) and basal ganglia (1.56 s), and dramatically shortened T1 in the muscle (0.71 s). In the animal treated with both BOMUS, Gd-DTPA not only shortened the T1 of the muscle (0.80 s), but also crossed the BBB and shortened T1 in the cortex (0.50 s) and basal ganglia (0.50 s).